3-trimethyloxypropylene | 60935-34-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-trimethyloxypropylene
• 英文别名: Acrylsaeureorthomethylester；1,1,1-trimethoxypropene；3,3,3-Trimethoxyprop-1-ene
• CAS: 60935-34-4
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: HWXOWLVWCZTSKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-乙氧基丙烯酸乙酯 、 3-trimethyloxypropylene 在 三氟化硼 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 4.0h， 以76.3%的产率得到ethyl 2-((4R,6S)-6-hydroxymethyl-2-ethoxycarbonylmethyl-1,3-dioxan-4-yl)acetate
  参考文献：
  名称：

  一种2-((4R,6S)-6-取代甲基-2-取代基-1,3-二 氧六环-4-基)乙酸酯的制备方法

  摘要：

  本发明涉及一种2-((4R,6S)-6-取代甲基-2-取代基-1,3-二氧六环-4-基)乙酸酯的制备方法。本发明利用取代乙烯和3,3-二烷氧基丙酸酯或3-烷氧基丙烯酸酯，在路易斯酸催化下制备2-((4R,6S)-6-取代甲基-2-酯基甲基-1,3-二氧六环-4-基)乙酸酯；然后通过水解开环、保护成环制得2-((4R,6S)-6-氯甲基-2-取代苯基-1,3-二氧六环-4-基)乙酸乙酯，再次水解开环并与羰基化合物Ⅹ或其缩二醇Ⅺ成环保护，得2-((4R,6S)-6-取代甲基-2-取代基-1,3-二氧六环-4-基)乙酸酯。本发明利用六元环椅式结构平伏键的稳定形式构建手性中心，不另外使用手性辅助剂。本发明原料易得，反应流程短，并且避免了羰基的不对称还原，不使用易燃易爆还原剂，简便且环保，适合于规模化工业生产。

  公开号：

  CN104163808B
• 作为产物：
  描述：

  甲醇 、 3,3-二甲氧基环丙烯 生成 3-trimethyloxypropylene
  参考文献：
  名称：

  Reaction of cyclopropenone ketals with alcohols

  摘要：

  DOI：

  10.1021/jo00424a022

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS
  申请人：COOPER EDWARD MICHAEL

  公开号：US20060239922A1

  公开（公告）日：2006-10-26

  Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 R 11 , R 12 , R 13 and R 14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 comprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.

  揭示了一种对于标记和检测生物和其他材料有用的青霉素染料。该染料的化学式为（I）：其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13和R14中的至少一个是-L-M或-L-P，其中L是连接基团，M是目标键合基团，P是共轭组分，并且R3、R4、R5、R6、R7、R8、R9和R10中的至少一个包含氟。通过用氟取代并具有三个或更多磺酸基团的青霉素染料标记生物靶分子，得到的标记产品中减少了染料-染料聚集并提高了光稳定性，与没有这种取代的青霉素染料相比。本发明的染料在涉及荧光检测的分析中特别有用，其中需要连续或重复激发，例如在动力学研究中，或在微阵列分析中，微阵列玻片可能需要在数天内重新分析。
• [EN] CYANIN-TYPE COMPOUNDS HAVING AN ALKYNYL LINKER ARM<br/>[FR] COMPOSES DE TYPE CYANINE AVEC BRAS ALKYNYLE DE LIAISON
  申请人：CAPUTO GIUSEPPE

  公开号：WO2005014723A1

  公开（公告）日：2005-02-17

  The invention relates to cyanine-type fluorescent dyes modified with an alkynyl linker arm of formula (I), suitable for the conjugation of biomolecules, such as for example nucleosides, nucleotides, oligonucleotides, nucleic acids, proteins, peptides, vitamins and hormones. A method and intermediates for the synthsis of the alkynyl cyanines of the invention are also described, as well as alkynyl cyanine­biomolecule conjugates and methods for preparing thereof. The alkynyl cyanines of the invention can be advantageously used as markers for biomolecules or as quenchers.

  该发明涉及一种具有式(I)的炔基连接臂修饰的青霉素类荧光染料，适用于与生物分子结合，例如核苷，核苷酸，寡核苷酸，核酸，蛋白质，肽，维生素和激素等。该发明还描述了用于合成炔基青霉素的方法和中间体，以及炔基青霉素-生物分子共轭物和其制备方法。该发明的炔基青霉素可以优势地用作生物分子的标记物或猝灭剂。
• [EN] A FUNCTIONALIZED CYANINE HAVING A SILANE LINKER ARM, A METHOD OF PREPARING THEREOF AND USES THEREOF<br/>[FR] CYANINE FONCTIONNALISÉE AYANT UN BRAS LIEUR SILANE, PROCÉDÉ DE PRÉPARATION ET APPLICATIONS ASSOCIÉS
  申请人：UNIV DEGLI STUDI TORINO

  公开号：WO2010046856A1

  公开（公告）日：2010-04-29

  There is disclosed a silane-modified cyanine of Formula (I) including the valence tautomers thereof: wherein R1 is a linear, saturated or unsaturated alkyl chain, having 1 to 30 carbon atoms, wherein one or more carbon atoms are optionally substituted by a 4-, 5- or 6-membered aromatic or non aromatic cyclic grouping of carbon atoms; R8 and R9 are independently selected from the group consisting of -OCH3, -OCH2CH3, -OCH2CH2CH3, -OCH(CH3)2,-OCH2CH2OCH3, -Cl, -Br, -I, Formula (II), Formula (III), -N(CH3)2, Formula (IV), Formula (V), methyl, ethyl, propyl, isopropyl; The synthesis method and the use as a fluorescent marker for inorganic solid supports, for example silica nanoparticles, and/or for biomolecules such as peptides, antibodies, DNA, RNA, etc., are also disclosed.

  本发明揭示了一种改性硅烷基靛氰染料，其化学式为(I)，包括其氢键互变体： 其中，R1是一种线性、饱和或不饱和的烷基链，具有1至30个碳原子，其中一个或多个碳原子可以被4-、5-或6-成员芳香或非芳香环状碳原子取代；R8和R9独立地选自-OCH3、-OCH2CH3、-OCH2CH2CH3、-OCH(CH3)2、-OCH2CH2OCH3、-Cl、-Br、-I、化学式(II)、化学式(III)、-N(CH3)2、化学式(IV)、化学式(V)、甲基、乙基、丙基、异丙基；本发明还揭示了该染料的合成方法以及其用作无机固体支持物（例如二氧化硅纳米颗粒）和/或生物分子（如肽、抗体、DNA、RNA等）的荧光标记剂。
• REAGENTS AND METHODS FOR DIRECT LABELING OF NUCLEOTIDES
  申请人：MARKER GENE TECHNOLOGIES, INC.

  公开号：US20150152476A1

  公开（公告）日：2015-06-04

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活的重氮衍生物以用于标记核苷酸的系统和方法。标记核苷酸是通过将可检测基团的稳定肼基衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成的。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，因此所有类型的核苷酸都可以在不进行扩增或改变的情况下进行标记。