(-)-(2R,3E)-3-methyl-3-penten-1,2-diol | 183322-89-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-(2R,3E)-3-methyl-3-penten-1,2-diol
• CAS: 183322-89-6
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: IRGJLURNJXLEBQ-QVQDZQDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.31
• 重原子数：
  8.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (-)-(2R,3E)-3-methyl-3-penten-1,2-diol 在 咪唑 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 18.17h， 生成
  参考文献：
  名称：

  Asymmetric epoxidation of chiral allylic alcohols

  摘要：

  Two series of chiral allylic alcohols, derived from alpha,beta-unsaturated cyanohydrins, were subjected to asymmetric epoxidation under a variety of conditions. Both achiral (organic peracid, metal-catalyzed peroxide) and chiral (Sharpless titanium-tartrate system) oxidants were applied. Several three and all theoretically possible erythro epoxides were isolated in enantiomerically and diastereomerically pure form. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00327-8
• 作为产物：
  描述：

  methyl (-)-(2R,3E)-2-hydroxy-3-methylpent-3-enoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以99%的产率得到(-)-(2R,3E)-3-methyl-3-penten-1,2-diol
  参考文献：
  名称：

  Asymmetric epoxidation of chiral allylic alcohols

  摘要：

  Two series of chiral allylic alcohols, derived from alpha,beta-unsaturated cyanohydrins, were subjected to asymmetric epoxidation under a variety of conditions. Both achiral (organic peracid, metal-catalyzed peroxide) and chiral (Sharpless titanium-tartrate system) oxidants were applied. Several three and all theoretically possible erythro epoxides were isolated in enantiomerically and diastereomerically pure form. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00327-8

文献信息

• Asymmetric epoxidation of chiral allylic alcohols
  作者：Erwin G.J.C. Warmerdam、Adrianus M.C.H. van den Nieuwendijk、Johannes Brussee、Chris G. Kruse、Arne van der Gen

  DOI：10.1016/0957-4166(96)00327-8

  日期：1996.9

  Two series of chiral allylic alcohols, derived from alpha,beta-unsaturated cyanohydrins, were subjected to asymmetric epoxidation under a variety of conditions. Both achiral (organic peracid, metal-catalyzed peroxide) and chiral (Sharpless titanium-tartrate system) oxidants were applied. Several three and all theoretically possible erythro epoxides were isolated in enantiomerically and diastereomerically pure form. Copyright (C) 1996 Elsevier Science Ltd