methyl 6-amino-5-chloroquinoline-7-carboxylate | 927430-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 6-amino-5-chloroquinoline-7-carboxylate
• CAS: 927430-35-1
• 化学式: C₁₁H₉ClN₂O₂
• 分子量: 236.658
• InChiKey: AZOXSNNCQNSRSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 6-amino-5-chloroquinoline-7-carboxylate 在 吡啶 、 甲基磺酰氯 、 potassium hydroxide 作用下， 以 1,4-二氧六环 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成 2-[5-bromo-2-(3-chloro-2-pyridyl)pyrazol-3-yl]-10-chloropyrido[2,3-g][3,1]benzoxazin-4-one
  参考文献：
  名称：

  Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity

  摘要：

  The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.11.035
• 作为产物：
  描述：

  methyl 6-aminoquinoline-7-carboxylate 在 N-氯代丁二酰亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以92%的产率得到methyl 6-amino-5-chloroquinoline-7-carboxylate
  参考文献：
  名称：

  Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity

  摘要：

  The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.11.035

文献信息

• NOVEL INSECTICIDES
  申请人：Jeanguenat Andre

  公开号：US20090221587A1

  公开（公告）日：2009-09-03

  Compounds of formula (I), wherein the substituents are as defined in claim ( 1 ), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se.

  公式（I）的化合物，其中取代基如权利要求（1）所定义，以及公式（I）化合物的农药可接受盐和所有立体异构体和互变异构体形式均可用作农药活性成分，并可按已知方法制备。
• BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES
  申请人：Syngenta Participations AG

  公开号：EP1919903B1

  公开（公告）日：2010-01-27
• US8580785B2
  申请人：——

  公开号：US8580785B2

  公开（公告）日：2013-11-12
• [EN] NOVEL INSECTICIDES<br/>[FR] NOUVEAUX INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2007020050A2

  公开（公告）日：2007-02-22

  [EN] Compounds of formula (I), wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se.
  [FR] L'invention concerne des composés de formule (I) ; les substituants (1) étant tels que définis dans la revendication (1) ; les sels acceptables sur le plan agrochimique ainsi que tous les stéréoisomères et les formes tautomères des composés de formule (I) pouvant servir de matières actives agrochimiques et préparés selon un procédé connu.
• Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity
  作者：André Jeanguenat、Patricia Durieux、Andrew J.F. Edmunds、Roger G. Hall、Dave Hughes、Olivier Loiseleur、Jagadish Pabba、André Stoller、Stephan Trah、Jean Wenger、Anna Dutton、Andrew Crossthwaite

  DOI：10.1016/j.bmc.2015.11.035

  日期：2016.2

  The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations. (C) 2015 Elsevier Ltd. All rights reserved.