3-(3-Methoxy-4-aethoxy-benzoyl)-propionsaeure | 854677-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3-Methoxy-4-aethoxy-benzoyl)-propionsaeure
• 英文别名: 4-(4-ethoxy-3-methoxy-phenyl)-4-oxo-butyric acid；4-(4-Aethoxy-3-methoxy-phenyl)-4-oxo-buttersaeure；4-(4-Ethoxy-3-methoxyphenyl)-4-oxobutanoic acid；4-(4-ethoxy-3-methoxyphenyl)-4-oxobutanoic acid
• CAS: 854677-96-6
• 化学式: C₁₃H₁₆O₅
• 分子量: 252.267
• InChiKey: LVXSUQRRPKWSRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(3-Methoxy-4-aethoxy-benzoyl)-propionsaeure 在 盐酸 、 磷酸 、 汞 、 锌 作用下， 以 甲苯 为溶剂， 生成 6-Methoxy-7-aethoxy-1-oxo-tetralin
  参考文献：
  名称：

  Traverso,G., Gazzetta Chimica Italiana, 1960, vol. 90, p. 778 - 791

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙氧基-3-甲氧基苯甲酸 在 氯化亚砜 、 乙醚 、 乙醇 、 sodium ethanolate 作用下， 生成 3-(3-Methoxy-4-aethoxy-benzoyl)-propionsaeure
  参考文献：
  名称：

  220.天然酚醛树脂的成分。第七部分 Arctigenin

  摘要：

  DOI：

  10.1039/jr9360000998

文献信息

• Chromosomal alterations and male infertility
  作者：A. Antonelli、L. Gandini、P. Petrinelli、L. Marcucci、R. Elli、F. Lombardo、F. Dondero、Andrea Lenzi

  DOI：10.1007/bf03343793

  日期：2000.11

  Reduced male fertility can be caused by genetic factors affecting gamete formation or function; in particular, chromosome abnormalities are a possible cause of male subfertility as shown by their higher frequency in infertile men than in the general male population. Meiotic studies in a number of these males have shown spermatogenesis breakdown, often related to alterations in the process of chromosome synapsis. Indeed, any condition that can interfere with X-Y bivalent formation and X-chromosome inactivation is critical to the meiotic process; furthermore, asynapsed regions may themselves represent a signal for the meiotic checkpoint that eliminates spermatocytes with synaptic errors. We performed cytogenetic, hormonal and seminal studies in 333 infertile patients selected because azoospermic, severely oligozoospermic or normozoospermic with failure to fertilize the partner's oocytes in an in vitro fertilization (IVF) program. Our findings: 1) confirm the high incidence of chromosomal anomalies among infertile males; 2) highlight the relevance in male infertility of quantitative/positional modifications of the constitutive heterochromatin; and 3) underline the relevance of cooperation between andrologists and cytogenetists prior to every kind of assisted reproduction, above all prior to intracytoplasmic sperm injection, in which selective hurdles eliminating abnormal germ cells are bypassed. (C) 2000, Editrice Kurtis.
• 220. The constituents of natural phenolic resins. Part VII. Arctigenin
  作者：Robert D. Haworth、William Kelly

  DOI：10.1039/jr9360000998

  日期：——
• Traverso,G., Gazzetta Chimica Italiana, 1960, vol. 90, p. 778 - 791
  作者：Traverso,G.

  DOI：——

  日期：——