1-O-Methyl-D-mannit | 14133-55-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-O-Methyl-D-mannit
• 英文别名: (2R,3R,4R,5R)-6-methoxyhexane-1,2,3,4,5-pentol
• CAS: 14133-55-2
• 化学式: C₇H₁₆O₆
• 分子量: 196.2
• InChiKey: PUTTXFZTELBTST-DBRKOABJSA-N

物化性质

• 熔点：
  119 °C(Solv: methanol (67-56-1))
• 沸点：
  475.3±45.0 °C(Predicted)
• 密度：
  1.406±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-O-Methyl-D-mannit 在 硝酸 、 乙酸酐 作用下， 生成 O¹-methyl-penta-O-nitro-D-mannitol
  参考文献：
  名称：

  Derivatives of D-Mannitol 1,2,3,5,6-Pentanitrate¹

  摘要：

  DOI：

  10.1021/ja01530a043
• 作为产物：
  描述：

  O¹-methyl-D-fructose 在 乙醇 、 镍 作用下， 生成 1-O-Methyl-D-mannit
  参考文献：
  名称：

  Bayne; Wildy, Journal of the Chemical Society, 1954, p. 1147

  摘要：

  DOI：

文献信息

• Ring scission of cyclic acetals. Part III. Reaction of acetyl trifluoroacetate with 1,3:2,5:4,6-tri-O-methylene-D-mannitol
  作者：T. G. Bonner、E. J. Bourne、D. Lewis

  DOI：10.1039/j39670002321

  日期：——

  The ring fission reaction of 1,3:2,5:4,6-tri-O-methylene-D-mannitol has been studied with the acetylating reagent formed from the 1 : 1 molar mixture of trifluoroacetic anhydride and acetic acid. Among a variety of acetals which have been identified are an O-acetoxymethyl-O-acetyl-1,3:2,5-di-O-methylene-, a di-O-acetoxymethyl-di-O-acetyl-2,5-O-methylene-, an O-acetyl-1,3:2,5-di-O-methylene-, 1,6-di-O-acetyl-2

  已经研究了由由三氟乙酸酐和乙酸的1：1摩尔混合物形成的乙酰化试剂进行的1,3：2,5：4,6-三-O-亚甲基-D-甘露醇的环裂变反应。在多种缩醛的已被识别是一个ö -acetoxymethyl- ø -乙酰基-1,3：2,5-二- ø亚甲基，二- Ô -acetoxymethyl二ø -乙酰基-2,5- - ø亚甲基，一个ø -乙酰基-1,3：2,5-二- ø亚甲基，1,6-二- ø -乙酰基-2,5- ö亚甲基，1,6-二- Ø乙酰基-2,5- Ø亚甲基-3,4- Ø-氧二亚甲基-和1 - O-乙酰基-3- O-烷氧基甲基-2,5：4,6-二-O-亚甲基化合物。提出解释这些产物形成的机理是基于开环反应，其中形成了O-乙酰基和O-三氟乙酰氧基甲基反应中间体。
• NOVELCROSSLINKING REAGENTS, MACROMOLECULES, THERAPEUTIC CONJUGATES, AND SYNTHETIC METHODS THEREOF
  申请人：CellMosaic, Inc.

  公开号：US20140206903A1

  公开（公告）日：2014-07-24

  The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

  本发明提供了基于糖醇的新型化合物。这些新型化合物具有生物相容性和生物可降解性。这些分子可以以单一纯形式制备。这些分子的分子量范围从小分子（<1000 Da）到大分子（1000-120,000 Da）。基于糖醇的分子可以在整个分子中具有功能性基团，用于交联化合物，例如制备抗体药物偶联物，或促进治疗性蛋白质、肽、siRNA和化学治疗药物的传递。还提供了通过糖醇分子制备的新型偶联实体。本发明还涉及制备基于糖醇的分子和偶联物的方法。
• Process for the preparation of polymeric biosurfactants
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US10106627B2

  公开（公告）日：2018-10-23

  The present invention relates to polymeric biosurfactants isolated from two bacterial strains of Microbacterium sp. strain BS-2 [MTCC 5822] and Brevibacillus sp. strain BS-207 [MTCC 5823]. The present invention relates to an acidic exopolysaccharide (EPS), termed Microsan, with chemical composition of glucose, mannose and glucuronic acid (β-D-glucuronyl-(1-2)-D-mannosyl-(1-4)-D-glucose) produced by Microbacterium sp. strain BS-2 and a neutral EPS, termed Brevisan, of galactomannan with galactose and mannose residues in the ratio of 1:1 produced by Brevibacillus sp. strain BS-207. Both these polysaccharides exhibited surface-active and potential antibacterial, antioxidant, anti-inflammatory, and immunomodulatory activities.

  本发明涉及从微杆菌 BS-2 株[MTCC 5822]和芽孢杆菌 BS-207 株[MTCC 5823]两株细菌中分离出来的高分子生物表面活性剂。本发明涉及一种由微细菌菌株 BS-2 产生的酸性外多糖（EPS），称为 Microsan，其化学成分为葡萄糖、甘露糖和葡萄糖醛酸（β-D-葡萄糖醛酸基-(1-2)-D-甘露糖基-(1-4)-D-葡萄糖）；以及一种由乳酸杆菌菌株 BS-207 产生的中性外多糖，称为 Brevisan，其化学成分为半乳甘露聚糖，半乳糖和甘露糖残基的比例为 1:1。这两种多糖都具有表面活性和潜在的抗菌、抗氧化、抗炎和免疫调节活性。
• Inbred corn plant WQDS7 and seeds thereof
  申请人：DEKALB GENETICS CORPORATION

  公开号：US20010044942A1

  公开（公告）日：2001-11-22

  According to the invention, there is provided an inbred corn plant designated WQDS7. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant WQDS7, and to methods for producing a corn plant produced by crossing the inbred corn plant WQDS7 with itself or with another corn plant, such as another inbred, This invention further relates to corn seeds and plants produced by crossing the inbred plant WQDS7 with another corn plant, such as another inbred, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of the inbred corn plant WQDS7, and also to the SSR and genetic isozyme typing profiles of inbred corn plant WQDS7.

  根据本发明，提供了一种名为 WQDS7 的近交玉米植株。因此，本发明涉及近交系玉米植株 WQDS7 的植株、种子和组织培养物，以及通过近交系玉米植株 WQDS7 与自身杂交或与另一种玉米植株（如另一种近交系植株）杂交生产玉米植株的方法，本发明还涉及通过近交系植株 WQDS7 与另一种玉米植株（如另一种近交系植株）杂交生产的玉米种子和植株，以及与相关物种杂交的方法。本发明还涉及近交系玉米植株 WQDS7 的近交系和杂交基因互补体，以及近交系玉米植株 WQDS7 的 SSR 和基因同工酶分型图谱。
• Inbred corn plant 6077 and seeds thereof
  申请人：ASGROW SEED COMPANY LLC

  公开号：US20010044944A1

  公开（公告）日：2001-11-22

  According to the invention, there is provided an inbred corn plant designated 6077. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant 6077, and to methods for producing a corn plant produced by crossing the inbred corn plant 6077 with itself or with another corn plant, such as another inbred. This invention further relates to corn seeds and plants produced by crossing the inbred plant 6077 with another corn plant, such as another inbred, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of the inbred corn plant 6077, and also to the SSR and genetic isozyme typing profiles of inbred corn plant 6077.

  根据本发明，提供了一种名为 6077 的近交玉米植株。因此，本发明涉及近交系玉米植株 6077 的植株、种子和组织培养物，以及通过近交系玉米植株 6077 与自身或与另一种玉米植株（如另一种近交系植株）杂交生产玉米植株的方法。本发明还涉及通过近交系玉米植株 6077 与另一种玉米植株（如另一种近交系植株）杂交生产的玉米种子和植株，以及与相关物种杂交生产的玉米种子和植株。本发明还涉及近交系玉米植株 6077 的近交种和杂交种基因补体，以及近交系玉米植株 6077 的 SSR 和基因同工酶分型图谱。