1-Methylamino-1-desoxy-D-fructose | 71231-87-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methylamino-1-desoxy-D-fructose
• 英文别名: (3S,4R,5R)-3,4,5,6-tetrahydroxy-1-(methylamino)hexan-2-one
• CAS: 71231-87-3
• 化学式: C₇H₁₅NO₅
• 分子量: 193.2
• InChiKey: KJPUOMSDQAYQLZ-FSDSQADBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-Methylamino-1-desoxy-D-fructose 、 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以94%的产率得到5(R,S)-hydroxy-3-methyl-1-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-5-(D-arabinotetritol-1-yl)imidazolidine-2-thione
  参考文献：
  名称：

  Chiral thioxohydroimidazoles with two sugar moieties. N-, C-, and spiro-nucleosides

  摘要：

  2-Amino (alkyl and arylamino)-2-deoxy-D-fructose and different sugar isothiocyanates are used in the diastereoselective synthesis of chiral imidazolidine-2-thione hi-nucleosides 12-23. Water beta-elimination of these compounds produces imidazoline-2-thione N-nucleosides 27-31, whereas cyclodehydration of the same products gives, with high stereoselectivity, chiral spironucleosides with an N-glycosyl radical 34-37. Conformational aspects of some of the prepared compounds are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00550-9
• 作为产物：
  描述：

  1-(Methyl-benzylamino)-1-desoxy-D-fructose 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 1-Methylamino-1-desoxy-D-fructose
  参考文献：
  名称：

  用于合成1-烷基氨基-1-脱氧-D-果糖酶。3.关于氨基糖的交流

  摘要：

  用烷基苄基胺，D-葡萄糖经AMADORI重排成1-烷基-苄基氨基-1-脱氧-D-果糖。苄基的催化氢解产生1-烷基氨基-1-脱氧-D-果糖（烷基果糖胺）。这样，果糖胺的甲基，乙基和丁基衍生物就已经制备成结晶形式，如异氰酸和罗丹酸一样，将1-烷基氨基-1-脱氧-D-果糖酶转化为咪唑衍生物，正如对果糖的物质所期望的那样。 α-氨基酮型。

  DOI：

  10.1002/hlca.19600430315

文献信息

• COMPOSITIONS FOR THE TREATMENT OF INTESTINAL DISORDERS
  申请人：NOVINTETHICAL PHARMA SA

  公开号：US20190209647A1

  公开（公告）日：2019-07-11

  The invention provides a process for preparing a protein-polysaccharide conjugated product comprising: (a) preparing a mixture comprising pea protein, polysaccharide, and an appropriate polar solvent; wherein: the weight ratio between polysaccharide and protein is comprised from 20:80 to 60:40, and the pH of the solution is comprised from 8.0 to 10.5; and performing a Maillard reaction by heating the solution resulting from step (a) at an appropriate temperature for the necessary period of time to conjugate the protein and the polysaccharide. The invention further provides a conjugated product obtainable by the process of the invention, as well as pharmaceutical compositions comprising the conjugate and to their use in the treatment in gastrointestinal disorders. The conjugate of the invention shows a remarkable improvement in preventing and/or treating intestinal diseases, such as mucositis.
• US5541341A
  申请人：——

  公开号：US5541341A

  公开（公告）日：1996-07-30
• US5631389A
  申请人：——

  公开号：US5631389A

  公开（公告）日：1997-05-20
• US5750733A
  申请人：——

  公开号：US5750733A

  公开（公告）日：1998-05-12
• US5786468A
  申请人：——

  公开号：US5786468A

  公开（公告）日：1998-07-28