6-benzylamino-8-hydroxy-9-(β-D-ribofuranosyl)purine | 1427459-45-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-benzylamino-8-hydroxy-9-(β-D-ribofuranosyl)purine
• 英文别名: 6-Benzylamino-8-hydroxy-9-(beta-D-ribofuranosyl)purine；6-(benzylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7H-purin-8-one
• CAS: 1427459-45-7
• 化学式: C₁₇H₁₉N₅O₅
• 分子量: 373.368
• InChiKey: VJMLIHZBUACLPZ-XNIJJKJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  8-溴膘苷 在 双氧水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 6-benzylamino-8-hydroxy-9-(β-D-ribofuranosyl)purine
  参考文献：
  名称：

  6,8-DISUBSTITUTED PURINE COMPOSITIONS

  摘要：

  提供可用于药物和化妆品组合物和/或应用的6,8-二取代嘌呤。这些6,8-二取代嘌呤具有广泛的生物活性，例如抗炎、抗衰老等，以及其他在制药和化妆品应用中特别有用的活性。含有这些6,8-二取代嘌呤的化合物和组合物提供生长调节、分化、抗衰老和抗衰老特性，具有比迄今为止已知的类似物更好的选择性和效率，以及较低的毒性。

  公开号：

  US20130072506A1

文献信息

• 6, 8- DISUBSTITUTED PURINE COMPOSITIONS AND THEIR PHARMACEUTICAL AND COSMETIC USE
  申请人：Univerzita Palackého v Olomouci

  公开号：EP2755977A1

  公开（公告）日：2014-07-23
• [EN] 6, 8- DISUBSTITUTED PURINE COMPOSITIONS AND THEIR PHARMACEUTICAL AND COSMETIC USE<br/>[FR] COMPOSITIONS DE PURINES 6,8-DISUBSTITUÉES ET LEUR UTILISATION PHARMACEUTIQUE ET COSMÉTIQUE
  申请人：UNIV PALACKEHO

  公开号：WO2013037333A1

  公开（公告）日：2013-03-21

  6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8- disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore.
• 6,8-DISUBSTITUTED PURINE COMPOSITIONS
  申请人：ZAHAJSKA Lenka

  公开号：US20130072506A1

  公开（公告）日：2013-03-21

  6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8-disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore.

  提供可用于药物和化妆品组合物和/或应用的6,8-二取代嘌呤。这些6,8-二取代嘌呤具有广泛的生物活性，例如抗炎、抗衰老等，以及其他在制药和化妆品应用中特别有用的活性。含有这些6,8-二取代嘌呤的化合物和组合物提供生长调节、分化、抗衰老和抗衰老特性，具有比迄今为止已知的类似物更好的选择性和效率，以及较低的毒性。