1,4-Di--butan | 60431-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,4-Di--butan
• 英文别名: 1,4-di-pyrrol-1-yl-butane；1,4-Di-pyrrol-1-yl-butan；1-(4-Pyrrol-1-ylbutyl)pyrrole
• CAS: 60431-12-1
• 化学式: C₁₂H₁₆N₂
• 分子量: 188.272
• InChiKey: CSWNUEZMHKKMTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,4-Di--butan 在 platinum(IV) oxide 氢气 、 硝酸 、 乙酸酐 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， -78.0~25.0 ℃ 、101.33 kPa 条件下， 反应 35.58h， 生成
  参考文献：
  名称：

  A New DNA Minor Groove Binding Motif: Cross-Linked Lexitropsins

  摘要：

  The nitrogen atoms of central pyrrole rings on two separate tripyrrolecarboxamide strands were covalently linked through poly(methylene) chains to provide a novel class of lexitropsins potentially capable of B-DNA double-strand reading via the minor groove, CD titration experiments revealed increasingly enhanced binding of 1:1 stoichiometry to the poly(dA-dT)-poly(dA-dT) DNA from the tetrakis(methylene) linkage to the heptakis(methylene) linkage, suggesting gradually growing importance of the bidentate antiparallel side by side binding. Ethidium bromide fluorescence displacement experiments on both poly(dA-dT)-poly(dA-dT) and poly(dA)-poly(dT) DNA's supported this analysis by providing quantitative measurement of intrinsic binding constants. The heptakis(methylene) linkage offered a binding enhancement of approximately 1000 times compared with that of the monomer.

  DOI：

  10.1021/ja00095a001
• 作为产物：
  描述：

  吡咯 在 氨 、 sodium 作用下， 生成 1,4-Di--butan
  参考文献：
  名称：

  Production of nu-alkyl pyrroles

  摘要：

  公开号：

  US02488336A1

文献信息

• Radical Cycloaddition by Nickel(II) Complex-Catalyzed Electroreduction. A Method for Preparation of Pyrrolopyridine and Pyrrolopyrrole Derivatives.
  作者：Shigeko OZAKI、Shizue MITOH、Hidenobu OHMORI

  DOI：10.1248/cpb.44.2020

  日期：——

  Cycloalkano[α]pyrroles were obtained by reductive radical cycloaddition of 1-(2-iodoethyl)pyrrole and activated olefins or by cyclization of 1-(ω-iodoalkyl)pyrroles, through electroreduction of the iodides using nickel(II) complex as an electron-transfer catalyst.

  环烷基[α]吡咯是通过1-(2-碘乙基)吡咯与活化烯烃的还原自由基环加成反应，或通过对1-(ω-碘烷基)吡咯的环化反应而获得的，采用镍(II)络合物作为电子转移催化剂对碘化物进行电还原。
• METHOD FOR PREPARING 2-MERCAPTOBENZOTHIAZOLE
  申请人：Sennics Co., Ltd.

  公开号：US20180222875A1

  公开（公告）日：2018-08-09

  A method for preparing 2-mercaptobenzothiazole where the aniline method is adopted to perform reaction in the presence of a catalyst, and the catalyst includes sulfonic acid type imidazolium ionic liquid. The sulfonic acid type imidazolium ionic liquid is a type of acidic functionalized ionic liquid, and has the advantages of both a solid acid and a liquid acid. The sulfonic acid type imidazolium ionic liquid is adopted as an active ingredient of the catalyst, and may remarkably improve a conversion rate of the reaction raw materials and increase a yield of the 2-mercaptobenzothiazole. Meanwhile, due to the characteristics of high catalytic activity, no volatilization, low corrosion, high thermal stability and the like of the 2-mercaptobenzothiazole, the preparation method also has the comprehensive advantages of simple process, low cost, low tar yield, high environment friendliness and the like.