3-deoxy-D-xylo-hexono-1,4-lactone | 6936-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-deoxy-D-xylo-hexono-1,4-lactone
• 英文别名: 3-Deoxy-D-galactono-1,4-lactone (3-deoxy-D-xylo-hexono-1,4-lactone)；(3R,5R)-5-[(1R)-1,2-dihydroxyethyl]-3-hydroxyoxolan-2-one
• CAS: 6936-66-9
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: NSEFGBGANVMEIR-UOWFLXDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  3-deoxy-D-xylo-hexono-1,4-lactone 在 camphor-10-sulfonic acid 2-甲基-2-丁烯 、 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 生成 5-(2,2-二甲基-1,3-二氧戊环-4-基)-2,2-二甲基四氢呋喃并[2,3-d][1,3]二氧杂环戊烯
  参考文献：
  名称：

  Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors

  摘要：

  Five diastereomeric trideoxy-1,6-iminohexitols were synthesised, and their inhibitory activities were determined against selected glycosidases. For comparison, 1,4,5-trideoxy-l,5-imino-D-lyxo-hexitol, the 4-deoxy derivative of 1-deoxymannojirimicin, was prepared by enzymatic isomerisation of 6-azido-3,6-dideoxy-D-riho-hexose into the corresponding 2-ulose and subsequent hydrogenation accompanied by intramolecular reductive amination. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(00)00018-5
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 3-deoxy-D-xylo-hexono-1,4-lactone
  参考文献：
  名称：

  Sowden et al., Journal of the American Chemical Society, 1957, vol. 79, p. 6450,6452

  摘要：

  DOI：

文献信息

• Simple synthesis of (R)-Carnitine from d-Galactono-1,4-lactone
  作者：Mikael Bols、Inge Lundt、Christian Pedersen

  DOI：10.1016/s0040-4020(01)88143-6

  日期：——

  (R)-Carnitine was prepared by two simple, short and efficient syntheses starting from ld-galactono-1,4-lactone.

  （R）-肉碱是通过从ld-半乳糖-1,4-内酯开始的两种简单，简短和有效的合成方法制备的。
• Evans; Edgar; Hoff, Journal of the American Chemical Society, 1926, vol. 48, p. 2666,2674
  作者：Evans、Edgar、Hoff

  DOI：——

  日期：——
• Bock, Klaus; Lundt, Inge; Pedersen, Christian, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1986, vol. 40, # 3, p. 163 - 171
  作者：Bock, Klaus、Lundt, Inge、Pedersen, Christian

  DOI：——

  日期：——
• Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors
  作者：Søren M Andersen、Christian Ekhart、Inge Lundt、Arnold E Stütz

  DOI：10.1016/s0008-6215(00)00018-5

  日期：2000.5

  Five diastereomeric trideoxy-1,6-iminohexitols were synthesised, and their inhibitory activities were determined against selected glycosidases. For comparison, 1,4,5-trideoxy-l,5-imino-D-lyxo-hexitol, the 4-deoxy derivative of 1-deoxymannojirimicin, was prepared by enzymatic isomerisation of 6-azido-3,6-dideoxy-D-riho-hexose into the corresponding 2-ulose and subsequent hydrogenation accompanied by intramolecular reductive amination. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Sowden et al., Journal of the American Chemical Society, 1957, vol. 79, p. 6450,6452
  作者：Sowden et al.

  DOI：——

  日期：——