3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propylamine | 71794-29-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propylamine
• 英文别名: 2,5,8,11-Tetraoxatetradecan-14-amine；3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propan-1-amine
• CAS: 71794-29-1
• 化学式: C₁₀H₂₃NO₄
• 分子量: 221.297
• InChiKey: QMPRGGKWKDAMNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propylamine 、 2,6-bis(3-bromopropionamido)anthracene-9,10-dione 以 乙醇 为溶剂， 生成 3-[3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propylamino]-N-[6-[3-[3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propylamino]propanoylamino]-9,10-dioxoanthracen-2-yl]propanamide
  参考文献：
  名称：

  一系列蒽醌与DNA的结合。

  摘要：

  研究了一系列在其侧链带有一个至四个乙二醇单元的同源2，6-二取代蒽醌穿线嵌入剂的DNA结合特性。结合常数通过表面等离振子共振（SPR）测量。这些化合物以比富含GC的发夹略高的亲和力与富含AT的发夹结合。结合常数随着侧链长度的增加而降低。

  DOI：

  10.1016/j.bmcl.2003.10.054
• 作为产物：
  描述：

  三甘醇单甲醚 在 Rh/Al₂O₃ 氢气 作用下， 生成 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propylamine
  参考文献：
  名称：

  一系列蒽醌与DNA的结合。

  摘要：

  研究了一系列在其侧链带有一个至四个乙二醇单元的同源2，6-二取代蒽醌穿线嵌入剂的DNA结合特性。结合常数通过表面等离振子共振（SPR）测量。这些化合物以比富含GC的发夹略高的亲和力与富含AT的发夹结合。结合常数随着侧链长度的增加而降低。

  DOI：

  10.1016/j.bmcl.2003.10.054

文献信息

• [EN] BI-FUNCTIONAL MOLECULES TO DEGRADE CIRCULATING PROTEINS<br/>[FR] MOLÉCULES BI-FONCTIONNELLES POUR DÉGRADER DES PROTÉINES CIRCULANTES
  申请人：UNIV YALE

  公开号：WO2019199621A1

  公开（公告）日：2019-10-17

  The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are through.macrophage migration inhibitory factor (MIF) or immunoglubin G (IgG). The present invention is also directed to pharmaceutical compositions which comprise these bi- functional compounds as well as methods for treating disease states and/or conditions which are mediated through MIF/lgG or where MIF/lgG is a contributing factor to the development and perpetuation of diseases and/or conditions, especially including autoimmune diseases and cancer, among others. The purpose of the present invention is to provide a molecular strategy to lower plasma MIF/lgG level in patients with autoimmune diseases or certain types of cancers. The b.i -functional molecule construct is comprised of a MIF/IgQ-targeting motif, that is derived from small molecule MIF/lgG ligands, and an ASGPr- targeting motif that binds to hepatocyte asialoglycoprotein receptor ASGPr). The compounds selectively bind MIF or IgG in plasma and subsequently engage the endo-lysosomal pathway of hepatocytes through ASGPr. As a consequence, MIF/igG is internalized and degraded by hepatocytes, thus resulting in potential attenuation of corresponding disease symptoms which are modulated through MIF/igG.
• Binding of a homologous series of anthraquinones to DNA
  作者：Ruel E. McKnight、Jianguo Zhang、Dabney W. Dixon

  DOI：10.1016/j.bmcl.2003.10.054

  日期：2004.1

  The DNA binding characteristics of a series of homologous 2,6-disubstituted anthraquinone threading intercalators bearing one to four ethylene glycol units in their side chains have been studied. Binding constants were measured via surface plasmon resonance (SPR). These compounds bind to an AT-rich hairpin with slightly higher affinity than to a GC-rich hairpin. The binding constants decrease as the

  研究了一系列在其侧链带有一个至四个乙二醇单元的同源2，6-二取代蒽醌穿线嵌入剂的DNA结合特性。结合常数通过表面等离振子共振（SPR）测量。这些化合物以比富含GC的发夹略高的亲和力与富含AT的发夹结合。结合常数随着侧链长度的增加而降低。