Boc-Ser(PO3Et2)-OH | 84714-32-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ser(PO3Et2)-OH
• 英文别名: (2S)-3-diethoxyphosphoryloxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• CAS: 84714-32-9
• 化学式: C₁₂H₂₄NO₈P
• 分子量: 341.298
• InChiKey: KBJNJWHGVKTHDL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  22.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  120.39
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  Boc-Ser(PO3Et2)-OH 在 N-甲基吗啉 、 盐酸 、 氯甲酸异丁酯 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.55h， 生成 H-Ser(PO3Et2)-Leu-OBzl hydrochloride
  参考文献：
  名称：

  Perich, John W.; Alewood, Paul F.; Johns, R. B., Australian Journal of Chemistry, 1991, vol. 44, # 2, p. 233 - 252

  摘要：

  DOI：
• 作为产物：
  描述：

  Boc-Ser-ONb 在 palladium on activated charcoal 吡啶 、 氢气 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 6.0h， 生成 Boc-Ser(PO3Et2)-OH
  参考文献：
  名称：

  Perich, John W.; Alewood, Paul F.; Johns, R. B., Australian Journal of Chemistry, 1991, vol. 44, # 2, p. 233 - 252

  摘要：

  DOI：

文献信息

• Release of Covalently Bound Metabolites of Organophosphate Pesticides from Synthetic Dialkylphosphoseryl Peptides by Supercritical Fluid Extraction
  作者：Alenka Paquet、Shahamat U. Khan

  DOI：10.1021/jf00051a054

  日期：1995.3

  Two model peptides immobilized on a solid support (Wang resin), Boc-Ser(PO(3)Et(2))-Phe-Wang and Boc-Ser(PO(3)Ph(2))-Phe-Wang, and two nonimmobilized compounds, Boc-Ser(PO(3)Et(2))-OBzl and Boc-Ser(PO(3)Et(2))-Phe-OBzl, were prepared and subjected to a supercritical fluid extraction (SFE) process. Approximately one-third of the immobilized peptides were cleaved from the resin, and the alkyl-substituted phosphoseryl moieties were identified in the distillates by means of H-1- and P-31-NMR spectroscopy. The peptides that were not immobilized were redistilled during the SFE without any changes in their structures. The results indicate that metabolites of organophosphate pesticides covalently bound to serine residues in a protein chain in plants or grains could be released by SFE.
• An Efficient One-Pot Synthesis of<i>N</i>-Protected α-Amino-β-dialkoxyphosphinyloxy(diphenoxyphosphinyloxy)-carboxylic Acids (Phosphate-Group Esters of<i>O</i>-Phosphorylated<i>N</i>-Protected α-Amino-β-hydroxyamino Acids)
  作者：John W. Perich、Paul F. Alewood、R. B. Johns

  DOI：10.1055/s-1986-31710

  日期：——
• Perich, John W.; Valerio, Robert M.; Alewood, Paul F., Australian Journal of Chemistry, 1991, vol. 44, # 6, p. 771 - 778
  作者：Perich, John W.、Valerio, Robert M.、Alewood, Paul F.、Johns, R. B.

  DOI：——

  日期：——
• PERICH, JOHN W.;ALEWOOD, PAUL F.;JOHNS, R. B., AUSTRAL. J. CHEM., 44,(1991) N, C. 233-252
  作者：PERICH, JOHN W.、ALEWOOD, PAUL F.、JOHNS, R. B.

  DOI：——

  日期：——