| 1616869-62-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1616869-62-5
• 化学式: C₁₅H₁₁NO₃
• 分子量: 253.257
• InChiKey: LYCVUNJOKWELLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 2-溴丙二腈 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-dione
  参考文献：
  名称：

  Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3,3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent

  摘要：

  An efficient methodology for the synthesis of 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.027
• 作为产物：
  描述：

  4b,9b-dihydroxy-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one 在 ammonium acetate 、 溶剂黄146 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3,3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent

  摘要：

  An efficient methodology for the synthesis of 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.027

文献信息

• Synthesis of different isoindolone embedded heterocycles with phenolic subunits from a common intermediate, 3-(2′-hydroxyaroyl)-2,3-dihydroisoindol-1-ones
  作者：Ashis Kundu、Animesh Pramanik

  DOI：10.1016/j.tetlet.2014.06.064

  日期：2014.8

  A series of biologically important isoindolone embedded heterocycles such as tetracyclic 2,4-diamino-5-aryl-10-oxo-10H-1,10a-diazaindeno[2,1-a]indene-3-carbonitriles and tricyclic 1-aryl-3,5-dioxo-1H-imidazo-[3,4-b]isoindoles have been synthesized from an easily derived common intermediate, 3-(2′-hydroxyaroyl)-2,3-dihydroisoindol-1-ones. The significant advantages of the present methodologies are the

  一系列具有重要生物学意义的异吲哚酮嵌入的杂环，例如四环2,4-二氨基-5-芳基-10-氧代-10 H -1,10a-二氮杂茚并[2,1- a ]茚3腈和三环1-芳基-3，5-二氧代-1 H-咪唑基-[3，4- b ]异吲哚是由易于衍生的普通中间体3-（2'-羟基芳酰基）-2，3-二氢异吲哚-1-酮合成的。本方法的显着优点是使用简单且容易获得的起始原料和试剂，操作简便以及具有高原子经济性的产物的良好收率。
• The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the <i>ortho</i> selectivity of ninhydrin-phenol adducts
  作者：Suven Das、Suvendu Maity、Prasanta Ghosh、Arpita Dutta

  DOI：10.1080/00397911.2021.1960379

  日期：2021.9.17