2,2',6,6'-tetramethoxy-3,3'-diacrboxy-1,1'-biphenyl | 70388-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2',6,6'-tetramethoxy-3,3'-diacrboxy-1,1'-biphenyl
• 英文别名: 2,2',6,6'-Tetramethoxy-3,3'-dicarboxybiphenyl；2,6,2',6'-tetramethoxy-biphenyl-3,3'-dicarboxylic acid；2,6,2',6'-Tetramethoxy-biphenyl-3,3'-dicarbonsaeure；3-(3-carboxy-2,6-dimethoxyphenyl)-2,4-dimethoxybenzoic acid
• CAS: 70388-56-6；70388-54-4
• 化学式: C₁₈H₁₈O₈
• 分子量: 362.336
• InChiKey: FCWXAGVMHUYQNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2,2',6,6'-tetramethoxy-3,3'-diacrboxy-1,1'-biphenyl 在 氢碘酸 作用下， 以 水 为溶剂， 反应 2.0h， 以65%的产率得到6,6'-dimethoxy-3,3'-dicarboxy-2,2'-dihydroxy-1,1'-biphenyl
  参考文献：
  名称：

  Chiral nonracemic C2-symmetry biphenyls by desymmetrization of 6,6′,2,2′-tetramethoxy-1,1′-biphenyl

  摘要：

  Regioselective bromination of the title biphenyl 1 at the 3 and 3' positions and simultaneous desymmetrization of the biphenyl has been achieved. Metal-halide exchange at the 3,3' positions facilitated the introduction of functional groups in good yield. Regioselective reduction was obtained by using (CH3)(3)SiI, L-Selectride and HI according to the functional groups on the biphenyls. Resolution of 6,6',2,2'-tetramethoxy-3,3'-dimethyl-1,1'-biphenyl 3 was achieved by its conversion to the corresponding phosphorothioamidate diastereomers of the (S)-(-)-alpha -methylbenzylamine. The absolute configuration of (M)-(+)-3 was confirmed by X-ray analysis of the corresponding diastereomer. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00410-9
• 作为产物：
  描述：

  2,2',6,6'-tetramethoxybiphenyl 在 二硫化碳 、 sodium hydroxide 、 氯 、 三氯化铁 作用下， 生成 2,2',6,6'-tetramethoxy-3,3'-diacrboxy-1,1'-biphenyl
  参考文献：
  名称：

  Chaos and complexity in development

  摘要：

  The paper outlines some main features of chaos theory. Examples of chaotic systems in society and the environment are given. Spontaneous interaction of components, without being planned or directed, is known as 'self-organising behaviour'. Chaos is an essential aspect of this self organisation, occurring in many forms. A chaotic system is defined as one that shows sensitivity to initial conditions. If the errors relative to the initial conditions become too great, the system will eventually collapse. Development projects are sensitive to such initial conditions. In particular, two examples in development are outlined in some detail and commented upon. One is the occurrence of a project promoting self-organising systems among the poorest of the poor. The other outlines how rehabilitation after resettlement in a power project has transgressed the 'edge of chaos' socio-emotionally, in spite of the socio-economic development being good.

  DOI：

  10.1080/13504500109470070

文献信息

• Atropisomerism of biphenyl compounds. An Important role of o-substituted methoxy groups and fluorine atoms
  作者：Nobusuke Kawano、Masayoshi Okigawa、Noriko Hasaka、Isao Kouno、Yasuko Kawahara、Yohko Fujita

  DOI：10.1021/jo00315a032

  日期：1981.1
• KAWANO NOBUSUKE; OKIGAWA MASAYOSHY; HASAKA NORIKO; KOUNO ISAO; KAWAHARA Y+, J. ORG. CHEM., 1981, 46, NO 2, 389-392
  作者：KAWANO NOBUSUKE、 OKIGAWA MASAYOSHY、 HASAKA NORIKO、 KOUNO ISAO、 KAWAHARA Y+

  DOI：——

  日期：——
• Chaos and complexity in development
  作者：Lars H. Ekstrand、Rita Ray

  DOI：10.1080/13504500109470070

  日期：2001.6

  The paper outlines some main features of chaos theory. Examples of chaotic systems in society and the environment are given. Spontaneous interaction of components, without being planned or directed, is known as 'self-organising behaviour'. Chaos is an essential aspect of this self organisation, occurring in many forms. A chaotic system is defined as one that shows sensitivity to initial conditions. If the errors relative to the initial conditions become too great, the system will eventually collapse. Development projects are sensitive to such initial conditions. In particular, two examples in development are outlined in some detail and commented upon. One is the occurrence of a project promoting self-organising systems among the poorest of the poor. The other outlines how rehabilitation after resettlement in a power project has transgressed the 'edge of chaos' socio-emotionally, in spite of the socio-economic development being good.
• Chiral nonracemic C2-symmetry biphenyls by desymmetrization of 6,6′,2,2′-tetramethoxy-1,1′-biphenyl
  作者：Giovanna Delogu、Davide Fabbri、Maria Antonietta Dettori、Alessandra Forni、Gianluigi Casalone

  DOI：10.1016/s0957-4166(00)00410-9

  日期：2000.11

  Regioselective bromination of the title biphenyl 1 at the 3 and 3' positions and simultaneous desymmetrization of the biphenyl has been achieved. Metal-halide exchange at the 3,3' positions facilitated the introduction of functional groups in good yield. Regioselective reduction was obtained by using (CH3)(3)SiI, L-Selectride and HI according to the functional groups on the biphenyls. Resolution of 6,6',2,2'-tetramethoxy-3,3'-dimethyl-1,1'-biphenyl 3 was achieved by its conversion to the corresponding phosphorothioamidate diastereomers of the (S)-(-)-alpha -methylbenzylamine. The absolute configuration of (M)-(+)-3 was confirmed by X-ray analysis of the corresponding diastereomer. (C) 2000 Elsevier Science Ltd. All rights reserved.