phenylalanyltyrosine | 17355-18-9

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylalanyltyrosine
• 英文别名: 2-[(2-Azaniumyl-3-phenylpropanoyl)amino]-3-(4-hydroxyphenyl)propanoate
• CAS: 17355-18-9
• 化学式: C₁₈H₂₀N₂O₄
• 分子量: 328.368
• InChiKey: FSXRLASFHBWESK-UHFFFAOYSA-N

物化性质

• 沸点：
  642.2±55.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090
• 储存条件：
  -20°C

反应信息

• 作为反应物：
  描述：

  phenylalanyltyrosine 、 苯甲酰氯 生成
  参考文献：
  名称：

  MIKI, TOSANU;XOSOGAVA, YUKIXIRO;MIVA, MAMATSU;FUDZITA, YASUSI;ASANO, MASA+

  摘要：

  DOI：

文献信息

• Tyrosine derivatives and use
  申请人：Daiichi Seiyaku Co., Ltd.

  公开号：US04025644A1

  公开（公告）日：1977-05-24

  Compounds having the formula: ##STR1## wherein R.sub.1 is phenyl or cycloalkyl and the phenyl may have at least one substituent selected from the group consisting of lower alkyl, lower alkoxy, amino and nitro; R.sub.2 is hydrogen or lower alkyl; A is --CH.sub.2 O-- or --CH.sub.2 CH(O-lower alkyl)-; n is zero or 1 when R.sub.1 together with (A).sub.n is unsubstituted phenyl, R.sub.2 is lower alkyl; and R.sub.3 is hydrogen or lower alkoxy, have anti-ulcerousaction.

  具有以下结构式的化合物：##STR1## 其中 R.sub.1 是苯基或环烷基，苯基可能具有至少一种取代基，所选自较低烷基、较低烷氧基、氨基和硝基；R.sub.2 是氢或较低烷基；A 是--CH.sub.2 O--或--CH.sub.2 CH(O-较低烷基)-；当 R.sub.1 与 (A).sub.n 共同为未取代的苯基时，n 为零或1，R.sub.2 为较低烷基；而 R.sub.3 是氢或较低烷氧基，具有抗溃疡作用。
• Functional mono- and dinuclear peptide complexes featuring chemospecific κS- or η6-coordination of organometallic half-sandwich fragments
  作者：Ralf Stodt、Susan Gencaslan、André Frodl、Claudia Schmidt、William S Sheldrick

  DOI：10.1016/s0020-1693(03)00345-1

  日期：2003.11

  Treatment of the dipeptides H-Tyr-Trp-OH, H-Trp-Tyr-OH, H-Trp-Phe-OH and H-Phe-Tyr-OH with [(T,(6)- cymene)Ru(acetone)(3)].(CF3SO3)(2) (1) in CF3COOH leads to chemospecific eta(6)-coordination in the order of electron-donating ability Trp > Tyr > Phe in respective complexes of the type [(eta(6)-cymene)Ru(eta(6) -dipeptide)](CF3SO3)(2) (3-6) after 24-36 h at 20degreesC. An analogous thermodynamic chemospecificity was also established for the complexes [(eta(5) -Cp*)Ir(eta(6)-dipeptide)](CF3SO3)(2) (7, H-Phe-Trp-OH; 8, H-Phe-Tyr-OH). However, a time-dependent 1H NMR study of the reaction between [(eta(5) -Cp*)Ir(acetone)(3)] (CF3SO3)(2) (2) and H-Tyr-Phe-OH confirms an initial kinetic preference for eta(6)-coordination of the C-terminal arene, as is also apparent from product mixtures obtained after treating 2 with H-Trp-Phe-OH or H-Trp-Tyr-OH for 1-2 d at 50 degreesC. Dinuclear sandwich complexes of the type [(eta(5)-Cp *)Ir(mu(2)-H-Met-X-OH-eta(6)-X:kappa(2)N(M), S)Pt(en)](CF3SO3)(4) (9-11, X = Phe, Tyr, Trp) can be prepared in CF3COOH following initial N-terminal kappa(2)N(M), S chelation of the (en)Pt-II fragment by the methionine residue of the dipeptide. Chemospecific kappaS coordination of the [(eta(5)-Cp *)Ir(dppZ)](2+) fragment in [(eta(5)-Cp*)Ir(dppz) (H-2-HArg-Met-NH2-kappaS)](4+) (12), [(eta(5)-Cp*)Ir(dppz)}(2)(mu-H-2-Met -Met-OH-kappaS:kappaS')](5+) (13) and [(eta(5)-Cp*)Ir(dppz)(mu-H-Gly-Met-OH-kappaS:kappaN(G))Pt(terpy)](4+) (14) affords effective metallointercalators for DNA with binding constants K-b in the range 1.3-3.3 x 10(6) M-1 and marked melting temperature shifts DeltaT(m) of respectively 10.2, 15.2 and 11.2 degreesC. (C) 2003 Elsevier B.V. All rights reserved.
• BIOMARKERS FOR KIDNEY CANCER AND METHODS USING THE SAME
  申请人：Metabolon, Inc.

  公开号：EP2788763A2

  公开（公告）日：2014-10-15
• Methods and compositions for treating metabolic disorders
  申请人：Mootha Vamsi Krishna

  公开号：US20090143279A1

  公开（公告）日：2009-06-04

  The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
• US20140343865A1
  申请人：——

  公开号：US20140343865A1

  公开（公告）日：2014-11-20