1-[2-[2-(2-碘乙氧基)乙氧基]乙氧基]-2-甲氧基乙烷 | 143127-81-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[2-[2-(2-碘乙氧基)乙氧基]乙氧基]-2-甲氧基乙烷
• 中文别名: 2,5,8,11-四氧杂十三烷-13-碘
• 英文名称: 13-iodo-2,5,8,11-tetraoxatridecane
• 英文别名: 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl iodide；1-[2-[2-(2-iodoethoxy)ethoxy]ethoxy]-2-methoxyethane
• CAS: 143127-81-5
• 化学式: C₉H₁₉IO₄
• 分子量: 318.152
• InChiKey: KBOKJZSZVAHUPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[2-[2-(2-碘乙氧基)乙氧基]乙氧基]-2-甲氧基乙烷 在 caesium carbonate 、 potassium iodide 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 56.0h， 生成 C₅₇H₈₄N₄O₄S₅
  参考文献：
  名称：

  不对称乙醇取代可增强高性能光伏电子受体的介电常数和生态兼容性

  摘要：

  传统有机光伏材料的介电常数（ε r ）为3至4，限制了有机太阳能电池（OSC）功率转换效率（PCE）的进一步提高。在此，我们通过在Y6的吡咯单元上引入不对称的高极化低聚乙二醇侧链，设计并合成了稠环电子受体Y6-4O。与烷基化Y6 (ε r = 3.36) 相比，不对称乙醇化Y6-4O 显示出明显更高的ε r值（5.13）以及在非卤素溶剂中更好的溶解度。由于较高的 ε r值，相对于基于 PM6:Y6 的对照器件，使用甲苯加工的基于铸态 PM6:Y6-4O 的器件表现出较高的电荷分离产率、较慢的双分子复合动力学和较小的电压损失。因此，基于 PM6:Y6-4O 的器件实现了 15.2% 的高 PCE，而基于 PM6:Y6 的器件的 PCE 仅为 7.38%。 15.2% 是铸态非卤化加工 OSC 器件的最高 PCE，也远高于基于高介电常数 (ε r > 5) 有机光伏半导体的 OSC 的报告值 (<8

  DOI：

  10.1021/jacsau.1c00306
• 作为产物：
  描述：

  2,5,8,11-四氧杂十三烷-13-基4-甲基苯磺酸酯 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 18.0h， 以94%的产率得到1-[2-[2-(2-碘乙氧基)乙氧基]乙氧基]-2-甲氧基乙烷
  参考文献：
  名称：

  The Impact of Polyether Chain Length on the Iron Clearing Efficiency and Physiochemical Properties of Desferrithiocin Analogues

  摘要：

  (S)-2-(2,4-Dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid (2) was abandoned in clinical trials as an iron chelator for the treatment of iron overload disease because of its nephrotoxicity. However, subsequent investigations revealed that replacing the 4'-(HO) of 2 with a 3,6,9-trioxadecyloxy group, ligand 4, increased iron clearing efficiency (ICE) and ameliorated the renal toxicity of 2. This compelled a closer look at additional polyether analogues, the subject of this work. The 3,6,9,12-tetraoxatridecyloxy analogue of 4, chelator 5, an oil, had twice the ICE in rodents of 4, although its ICE in primates was reduced relative to 4. The corresponding 3,6-dioxaheptyloxy analogue of 2, 6 (a crystalline solid), had high ICEs in both the rodent and primate models. It significantly decorporated hepatic, renal, and cardiac iron, with no obvious histopathologies. These findings suggest that polyether chain length has a profound effect on ICE, tissue iron decorporation, and ligand physiochemical properties.

  DOI：

  10.1021/jm9018146

文献信息

• Adventures and Detours in the Synthesis of Hydropentalenes
  作者：Sabine Laschat、Max Deimling、Anna Zens、Natja Park、Christine Hess、Simon Klenk、Zarfishan Dilruba、Angelika Baro

  DOI：10.1055/s-0040-1707226

  日期：2021.1

  Hydropentalenes 3 Hydropentalenes through the Pauson–Khand Reaction 4 Hydropentalenes through Transannular Oxidative Cyclization of Cycloocta-1,4-diene 5 Functionalization of Bicyclo[3.3.0]octan-1,4-dione to Dodecahydrocyclopenta[a]indenes 6 Functionalization of Bicyclo[3.3.0]octan-1,4-diones to Crown Ether Hybrids 7 Functionalization of Bicyclo[3.3.0]octan-1,4-dione to Cylindramide 8 Tandem Ring-Opening

  功能化的氢戊烯（即双环[3.3.0]辛酮）是天然产物和不对称催化配体的重要组成部分。这种凸屋顶形脚手架的组装和定制功能化具有挑战性，并激发了各种合成方法，包括我们自己的贡献，这将在本帐户中介绍。1 引言 2 氢戊烯的生物合成 3 氢戊烯通过 Pauson-Khand 反应 4 氢戊烯通过环辛-1,4-二烯的跨环氧化环化 5 双环 [3.3.0] 辛烷-1,4-二酮官能化为十二氢环戊烷 [a] 烯6 双环[3.3.0]octan-1,4-二酮对冠醚杂化物的官能化 7 双环[3.3.0]octan-1的官能化，
• GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE
  申请人：SHANGHAI HUTCHISON PHARMACEUTICALS LIMITED

  公开号：US20210115082A1

  公开（公告）日：2021-04-22

  The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.

  本发明公开了一种由III式表示的糖苷化合物，以及其制备方法、组合物、用途和中间体。本发明提供的糖苷化合物具有简单的制备方法，可以显著增加VEGF-A mRNA的表达，并且在促进血管生成方面具有有效性。这为开发具有促血管生成活性的药物治疗脑梗死、脑卒中、心肌梗死和下肢缺血微循环障碍提供了可靠的保证。
• Polymerizable molten salt monomer, electrolyte composition and electrochemical cell
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US06750352B2

  公开（公告）日：2004-06-15

  A polymerizable molten salt monomer represented by the following general formula (I): wherein Q represents a nitrogen-containing aromatic heterocyclic atomic group which can form a cation; Y1 represents a divalent interlocking group or a bonding hand; Y2 represents a substituted or unsubstituted alkyl group; n represents an integer of from 2 to 20; m represents an integer of 2 or more; X− represents an anion; plural Y1's and plural Y2's may be the same or different, respectively, with the proviso that at least one of Y2's has a polymerizable substituent group; and a plurality of the compounds of the general formula (I) may be connected to each other at Q or Y2 to form a dimer, trimer or tetramer. Also disclosed are an electrolyte composition containing a polymer compound obtained by the polymerization of the molten salt monomer, and a cell containing the electrolyte composition.

  一种可聚合的熔融盐单体，其表示为以下一般式（I）：其中Q代表一个能形成阳离子的含氮芳香杂环原子团；Y1代表一个二价的嵌锁基团或结合手；Y2代表一个取代或未取代的烷基团；n表示2至20之间的整数；m表示2或更多的整数；X−代表一个阴离子；复数的Y1和复数的Y2可以分别相同或不同，但至少一个Y2具有可聚合取代基团；一系列符合一般式（I）的化合物可以在Q或Y2处连接在一起形成二聁体、三聁体或四聁体。还公开了一种包含通过聚合熔融盐单体获得的聚合物化合物的电解质组合物，以及包含该电解质组合物的电池。
• HIV protease inhibitors having polyether substituents
  申请人：MERCK & CO. INC.

  公开号：EP0487270A2

  公开（公告）日：1992-05-27

  Polyether derivatives of the form,         A-G-B-B-J    wherein G is a dipeptide isostere substituted with a polyether, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of DIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  描述了形式为A-G-B-B-J的聚醚衍生物，其中G是用聚醚取代的二肽同分异构体，B是氨基酸或其类似物，J是一个小的末端基团。这些化合物在抑制DIV蛋白酶、预防或治疗HIV感染以及治疗艾滋病方面具有用途，无论是作为化合物、药学上可接受的盐、药物组成成分，还是与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。还描述了治疗艾滋病的方法以及预防或治疗HIV感染的方法。
• Probing the Role of Glycol Chain Lengths in π-Donor–Acceptor [2]Pseudorotaxanes Based on Monopyrrolo-Tetrathiafulvalene and Cyclobis(paraquat-<i>p</i>-phenylene)
  作者：Rikke Kristensen、Sissel S. Andersen、Gunnar Olsen、Jan O. Jeppesen

  DOI：10.1021/acs.joc.6b02466

  日期：2017.2.3

  reveal that [C–H···O] hydrogen bonding interactions between the acidic α-H protons in CBPQT4+ and the oxygen atoms present in the glycol chain can take place on the exterior of the [2]pseudorotaxane. However, the length of the glycol chain is of paramount importance and the present studies show that the first and second oxygen atom in the [2]pseudorotaxanes 2–5⊂CBPQT4+ are engaged in [C–H···O] hydrogen

  我们已经研究并量化了乙二醇链长度对环双（百草枯-对苯撑）（CBPQT 4+）与五种不同的单吡咯并四硫富瓦烯（MPTTF）衍生物之间发生的非共价键相互作用的强度的作用在N-取代的二醇链的长度上。通过将MPTTF衍生物与CBPQT 4+混合，可用于形成[2]假轮烷。的结合常数（ķ一个与络合过程中导致的形成相关联）[2]使用的UV-vis-NIR稀释法和[2] pseudorotaxanes表征结构使用获得pseudorotaxanes 11 H NMR光谱。这些实验研究清楚地表明，乙二醇链为[2]假轮烷的发现提供了额外的稳定性，密度功能理论（DFT）研究进一步支持了这一发现。[2]设置准轮烷的DFT计算上层建筑3 ⊂CBPQT 4+揭示[C-H ... O]酸性α-之间的氢键相互作用ħ在CBPQT质子4+和氧原子存在于二醇链罐发生在[2]假轮烷的外部。然而，乙二醇链的长度是非常重要的，并且本研