methyl 2-(1,4-dioxaspiro[4.5]dec-7-yl)acetate | 38231-56-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-(1,4-dioxaspiro[4.5]dec-7-yl)acetate
• 英文别名: Methyl 2-(1,4-dioxaspiro[4.5]decan-7-yl)acetate；methyl 2-(1,4-dioxaspiro[4.5]decan-7-yl)acetate
• CAS: 38231-56-0
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: VTEWEDJARYOWIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(1,4-dioxaspiro[4.5]dec-7-yl)acetate 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 8.0h， 生成 30(2-hydroxyethyl)-1-cyclohexanone
  参考文献：
  名称：

  An Approach to the Synthesis of Stenine

  摘要：

  A type 2 N-acylnitroso intramolecular Diels-Alder reaction followed by reductive N-O bond cleavage formed the B and C rings of the Stemona alkaloid stenine. Further elaboration provided the functionalized tricyclic core.

  DOI：

  10.1021/ol070397c
• 作为产物：
  描述：

  2-(1,4-dioxaspiro[4.5]dec-7-yl)malonic acid dimethyl ester 在 水 、 lithium chloride 作用下， 以 二甲基亚砜 为溶剂， 反应 17.0h， 以59%的产率得到methyl 2-(1,4-dioxaspiro[4.5]dec-7-yl)acetate
  参考文献：
  名称：

  An Approach to the Synthesis of Stenine

  摘要：

  A type 2 N-acylnitroso intramolecular Diels-Alder reaction followed by reductive N-O bond cleavage formed the B and C rings of the Stemona alkaloid stenine. Further elaboration provided the functionalized tricyclic core.

  DOI：

  10.1021/ol070397c

文献信息

• PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS
  申请人：Abele Stefan

  公开号：US20130211104A1

  公开（公告）日：2013-08-15

  The present invention relates to a new process for the preparation of 6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): The present invention further relates to novel compounds as such, which compounds are useful intermediates in the above process.

  本发明涉及一种制备公式（II）的6-羟基-5-芳基双环[2.2.2]辛烷-2-酮化合物的新工艺，该化合物随后可进一步转化为公式（I）的化合物： 本发明还涉及上述过程中有用的新化合物作为中间体。
• Schmoldt, Philip; Mattay, Jochen, Synthesis, 2003, # 7, p. 1071 - 1078
  作者：Schmoldt, Philip、Mattay, Jochen

  DOI：——

  日期：——
• US9296673B2
  申请人：——

  公开号：US9296673B2

  公开（公告）日：2016-03-29
• [EN] PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS<br/>[FR] PRÉPARATION DE COMPOSÉS DE BICYCLO[2.2.2]OCTAN-2-ONE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012052939A2

  公开（公告）日：2012-04-26

  The present invention relates to a new process for the preparation of 6-hydroxy-5- arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): Formula (I) Formula (II). The present invention further relates to novel compounds as such, which compounds are useful intermediates in the above process.
• An Approach to the Synthesis of Stenine
  作者：Liang Zhu、Ryan Lauchli、Mandy Loo、Kenneth J. Shea

  DOI：10.1021/ol070397c

  日期：2007.6.1

  A type 2 N-acylnitroso intramolecular Diels-Alder reaction followed by reductive N-O bond cleavage formed the B and C rings of the Stemona alkaloid stenine. Further elaboration provided the functionalized tricyclic core.