(R)-3-[2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione | 908338-20-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-3-[2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione
• 英文别名: (R)-3-(2-(Aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl)-4-(phenylamino)-1H-pyrrole-2,5-dione；3-[(2R)-2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-4-yl]-4-anilinopyrrole-2,5-dione
• CAS: 908338-20-5
• 化学式: C₂₂H₂₀N₄O₂
• 分子量: 372.426
• InChiKey: VCGDMSXJUNSZGP-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  89.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-3-[2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione 、 乙酸酐 以 四氢呋喃 为溶剂， 反应 3.0h， 以51%的产率得到N-[[(2R)-4-(4-anilino-2,5-dioxopyrrol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl]methyl]acetamide
  参考文献：
  名称：

  Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

  摘要：

  Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase C beta (PKC beta)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-membered ring at the indole 1,2-position inhibited PKC beta 2 with IC50 of nM-order and showed good oral bioavailability. One of the most potent compounds was found to be PKC beta-selective over other 6 isozymes and exhibited ameliorative effects in a rat diabetic retinopathy model via oral route. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.033
• 作为产物：
  描述：

  2-(1H-indol-2-ylmethyl)propane-1,3-diol 在 Lipase PS 吡啶 、 咪唑 、 三乙基硅烷 、 sodium tetrahydroborate 、 potassium tert-butylate 、 四丁基氟化铵 、 氨 、 sodium hydride 、 potassium carbonate 、 溶剂黄146 、 三乙胺 、 三氟乙酸 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.67h， 生成 (R)-3-[2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

  摘要：

  Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase C beta (PKC beta)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-membered ring at the indole 1,2-position inhibited PKC beta 2 with IC50 of nM-order and showed good oral bioavailability. One of the most potent compounds was found to be PKC beta-selective over other 6 isozymes and exhibited ameliorative effects in a rat diabetic retinopathy model via oral route. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.033

文献信息

• One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane Ring-Opening Reaction:  Application to the PKCβ Inhibitor JTT-010
  作者：Masahiro Tanaka、Minoru Ubukata、Takafumi Matsuo、Katsutaka Yasue、Katsuya Matsumoto、Yasuyuki Kajimoto、Takashi Ogo、Takashi Inaba

  DOI：10.1021/ol071336h

  日期：2007.8.1

  A ring-opening reaction of cyclopropanes with five-membered heteroaromatics having a leaving group at C(2) was found to provide heteroaromatic-fused pyrrolidines in one step. This reaction was successfully applied to the synthesis of the protein kinase C-beta inhibitor JTT-010, which possesses a dihydropyrrolo[1,2-a]indole core.
• Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors
  作者：Masahiro Tanaka、Shoichi Sagawa、Jun-ichi Hoshi、Fumito Shimoma、Katsutaka Yasue、Minoru Ubukata、Tomoyuki Ikemoto、Yasunori Hase、Mitsuru Takahashi、Tomohiko Sasase、Nobuhisa Ueda、Mutsuyoshi Matsushita、Takashi Inaba

  DOI：10.1016/j.bmc.2006.05.033

  日期：2006.9

  Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase C beta (PKC beta)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-membered ring at the indole 1,2-position inhibited PKC beta 2 with IC50 of nM-order and showed good oral bioavailability. One of the most potent compounds was found to be PKC beta-selective over other 6 isozymes and exhibited ameliorative effects in a rat diabetic retinopathy model via oral route. (c) 2006 Elsevier Ltd. All rights reserved.