3-methyl-3,4-dihydro-1H-isoquinolin-2-amine | 127662-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-methyl-3,4-dihydro-1H-isoquinolin-2-amine
• CAS: 127662-56-0
• 化学式: C₁₀H₁₄N₂
• 分子量: 162.235
• InChiKey: WSGZXRUWPCTNKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-氯-3-氨磺酰基苯甲酰氯 、 3-methyl-3,4-dihydro-1H-isoquinolin-2-amine 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以48%的产率得到4-Chloro-N-(3-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-3-sulfamoyl-benzamide
  参考文献：
  名称：

  Landriani; Barlocco; Pinna, Il Farmaco, 1989, vol. 44, # 11, p. 1059 - 1068

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-1,2,3,4-四氢异喹啉 在 lithium aluminium tetrahydride 、 硫酸 、 亚硝酸异戊酯 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 3-methyl-3,4-dihydro-1H-isoquinolin-2-amine
  参考文献：
  名称：

  Carbazates as potent inhibitors of hormone-sensitive lipase

  摘要：

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.038

文献信息

• Carbazates as potent inhibitors of hormone-sensitive lipase
  作者：Johannes C. de Jong、Lotte G. Sørensen、Hans Tornqvist、Poul Jacobsen

  DOI：10.1016/j.bmcl.2004.01.038

  日期：2004.4

  The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. (C) 2004 Elsevier Ltd. All rights reserved.
• Landriani; Barlocco; Pinna, Il Farmaco, 1989, vol. 44, # 11, p. 1059 - 1068
  作者：Landriani、Barlocco、Pinna、Demontis、Miele、Enrico、Anania

  DOI：——

  日期：——