9-methoxymappicine | 142727-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-methoxymappicine
• 英文别名: (+/-)-1-Methoxy-7-(1-hydroxypropyl)-8-methylindolizino[1,2-b]quinolin-9(11H)-one；1-Methoxy-7-(1-hydroxypropyl)-8-methylindolizino[1,2-b]quinolin-9(11H)-one；7-(1-hydroxypropyl)-1-methoxy-8-methyl-11H-indolizino[1,2-b]quinolin-9-one
• CAS: 142727-79-5
• 化学式: C₂₀H₂₀N₂O₃
• 分子量: 336.39
• InChiKey: JNCFAGIFKYMLEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-methoxymappicine 在 phosphate buffer 、 lipase Amano PS (Pseudomonas cepacia) 、 potassium carbonate 作用下， 以 四氢呋喃 、 吡啶 、 甲醇 为溶剂， 反应 74.0h， 生成 (S)-9-methoxymappicine
  参考文献：
  名称：

  Enantioselective synthesis of (S)- and (R)-mappicines and their analogues

  摘要：

  The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to (S)- and (R)-mappicines in high optical purity using baker's yeast and a lipase, Amano PS. Treatment of the racemic acetate with baker's yeast afforded (S)-mappicine while with Amano PS yielded (R)-mappicine. 9-Methoxycamptothecin and 9-methoxymappicine ketone underwent similar conversion to (S)- and (R)-9-methxymappicines. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00397-x
• 作为产物：
  描述：

  9-甲氧基喜树碱 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.12h， 生成 9-methoxymappicine
  参考文献：
  名称：

  Enantioselective synthesis of (S)- and (R)-mappicines and their analogues

  摘要：

  The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to (S)- and (R)-mappicines in high optical purity using baker's yeast and a lipase, Amano PS. Treatment of the racemic acetate with baker's yeast afforded (S)-mappicine while with Amano PS yielded (R)-mappicine. 9-Methoxycamptothecin and 9-methoxymappicine ketone underwent similar conversion to (S)- and (R)-9-methxymappicines. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00397-x

文献信息

• Substituted indolizino\x9b1,2-b!quinolinones
  申请人：SmithKline Beecham Corporation

  公开号：US05883255A1

  公开（公告）日：1999-03-16

  The present invention provides a method of treating viral infections by using antiviral substituted indolizino\x9b1,2-b!quinolinone compounds, antiviral substituted indolizino\x9b1,2-b!quinolinone compounds, and pharmaceutical compositions thereof.

  本发明提供了一种使用抗病毒取代吲哚并咔啉酮化合物，抗病毒取代吲哚并咔啉酮化合物和其药物组合物治疗病毒感染的方法。
• Das; Madhusudhan, Journal of Chemical Research - Part S, 2000, # 10, p. 476 - 477
  作者：Das、Madhusudhan

  DOI：——

  日期：——
• US5883255A
  申请人：——

  公开号：US5883255A

  公开（公告）日：1999-03-16
• [EN] SUBSTITUTED INDOLIZINO[1,2-b]QUINOLINONES<br/>[FR] INDOLIZINO[1,2-b]QUINOLINONES SUBSTITUEES
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：WO1993020818A1

  公开（公告）日：1993-10-28

  (EN) The present invention provides a method of treating viral infections by using antiviral substituted indolizinol[1,2-b]quinolinone compounds, and pharmaceutical compositions thereof.(FR) La présente invention se rapporte à un procédé pour traiter les infections virales à l'aide de composés antiviraux d'indolizino[1,2-b]quinolinone substitués, et des compositions pharmaceutiques de ceux-ci.
• Enantioselective synthesis of (S)- and (R)-mappicines and their analogues
  作者：Biswanath Das、P. Madhusudhan

  DOI：10.1016/s0040-4020(99)00397-x

  日期：1999.6

  The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to (S)- and (R)-mappicines in high optical purity using baker's yeast and a lipase, Amano PS. Treatment of the racemic acetate with baker's yeast afforded (S)-mappicine while with Amano PS yielded (R)-mappicine. 9-Methoxycamptothecin and 9-methoxymappicine ketone underwent similar conversion to (S)- and (R)-9-methxymappicines. (C) 1999 Elsevier Science Ltd. All rights reserved.