N-[1-(benzylsulfanyl)-2-oxo-2-phenylethyl]acetamide | 1432104-80-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[1-(benzylsulfanyl)-2-oxo-2-phenylethyl]acetamide
• 英文别名: N-(1-benzylsulfanyl-2-oxo-2-phenylethyl)acetamide
• CAS: 1432104-80-7
• 化学式: C₁₇H₁₇NO₂S
• 分子量: 299.393
• InChiKey: NKPWBLNCUKPMHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[1-(benzylsulfanyl)-2-oxo-2-phenylethyl]acetamide 在 劳森试剂 、 氯 、 溶剂黄146 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 46.5h， 生成 2-methyl-N,5-diphenyl-1,3-thiazole-4-sulfonamide
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148
• 作为产物：
  描述：

  N-(1-氯-2-氧代-2-苯基乙基)-乙酰胺 、 苄硫醇 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以80%的产率得到N-[1-(benzylsulfanyl)-2-oxo-2-phenylethyl]acetamide
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148

文献信息

• Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides
  作者：A. N. Kornienko、S. G. Pil’o、V. M. Prokopenko、V. S. Brovarets

  DOI：10.1134/s1070363214040148

  日期：2014.4

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.