1-(4-methoxyphenyl)-2-[2-(methylthio)-4-pyrimidinyl]ethanone | 875757-74-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-methoxyphenyl)-2-[2-(methylthio)-4-pyrimidinyl]ethanone
• 英文别名: 1-(4-methoxy-phenyl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone；1-(4-Methoxyphenyl)-2-[2-(methylthio-4-pyrimidinyl)]-ethanone；1-(4-methoxyphenyl)-2-(2-methylsulfanylpyrimidin-4-yl)ethanone
• CAS: 875757-74-7
• 化学式: C₁₄H₁₄N₂O₂S
• 分子量: 274.343
• InChiKey: DGDDJCMTFISZLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-methoxyphenyl)-2-[2-(methylthio)-4-pyrimidinyl]ethanone 在 溴 、 溶剂黄146 作用下， 以99%的产率得到2-bromo-1-(4-methoxyphenyl)-2-[2-(methylthio)-4-pyrimidinyl]ethanone
  参考文献：
  名称：

  新型4-（2-氨基-5-噻唑基）-嘧啶-2-胺类化合物的合成作为潜在的蛋白激酶抑制剂

  摘要：

  摘要开发了合成一​​系列4-（2-氨基-5-噻唑基）-嘧啶-2-胺的短而有效的序列。通过Weinreb的方法获得的1-苯基-2-（6-嘧啶基）-乙炔用于汉茨噻唑环化反应，然后通过亲核取代引入苯胺部分。 图形概要

  DOI：

  10.1007/s00706-008-0047-9
• 作为产物：
  描述：

  4-甲基-2-甲硫基嘧啶 、 茴香酸乙酯 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 1-(4-methoxyphenyl)-2-[2-(methylthio)-4-pyrimidinyl]ethanone
  参考文献：
  名称：

  Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses

  摘要：

  Synthesis of several pyrazolo[1,5-c]pyrimidines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][ 1,3,5]triazines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.009

文献信息

• Condensed Pyridines as Kinase Inhibitors
  申请人：Almansa Rosales Carmen

  公开号：US20080318977A1

  公开（公告）日：2008-12-25

  New compounds of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

  新的化合物公式为（I），其中各种取代基的含义如描述中所披露。这些化合物可用作p38激酶抑制剂。
• CONDENSED PYRIDINES AS KINASE INHIBITORS
  申请人：Palau Pharma, S.A.

  公开号：EP1833828A2

  公开（公告）日：2007-09-19
• [EN] HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSES HETEROCYCLIQUES
  申请人：URIACH Y COMPANIA S A J

  公开号：WO2006013095A2

  公开（公告）日：2006-02-09

  New compounds of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.
• Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses
  作者：Kristjan S. Gudmundsson、Brian A. Johns、Jason Weatherhead

  DOI：10.1016/j.bmcl.2009.08.009

  日期：2009.10

  Synthesis of several pyrazolo[1,5-c]pyrimidines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][ 1,3,5]triazines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors
  作者：Marko P. Sušnik、Michael Schnürch、Marko D. Mihovilovic、Kurt Mereiter、Peter Stanetty

  DOI：10.1007/s00706-008-0047-9

  日期：2009.4

  AbstractA short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6-pyrimidinyl)-ethanones, obtained via Weinreb’s methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution. Graphical abstract

  摘要开发了合成一​​系列4-（2-氨基-5-噻唑基）-嘧啶-2-胺的短而有效的序列。通过Weinreb的方法获得的1-苯基-2-（6-嘧啶基）-乙炔用于汉茨噻唑环化反应，然后通过亲核取代引入苯胺部分。 图形概要