(4-nitro-phenyl)-fumaric acid | 127019-85-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (4-nitro-phenyl)-fumaric acid
• 英文别名: (4-Nitro-phenyl)-fumarsaeure；(E)-2-(4-nitrophenyl)but-2-enedioic acid
• CAS: 127019-85-6
• 化学式: C₁₀H₇NO₆
• 分子量: 237.169
• InChiKey: ANMYWFDSHIYRRL-VMPITWQZSA-N

物化性质

• 沸点：
  405.3±33.0 °C(Predicted)
• 密度：
  1.566±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-乙氧基-2-羟基乙酸乙酯 、 对硝基苯乙酸乙酯 在 苯甲酸酐 作用下， 生成 (4-nitro-phenyl)-fumaric acid 、 (4-nitro-phenyl)-maleic acid
  参考文献：
  名称：

  SYNTHESIS OF ARYLMALEIC ANHYDRIDES

  摘要：

  DOI：

  10.1021/jo01366a019

文献信息

• ACYL TRANSFER WITH STABILISED TRANSITION COMPLEX USING CATALYST WITH CATALYTIC IMIDAZOLE (E.G. HISTIDINE) FUNCTION
  申请人：A+Science Invest AB

  公开号：EP0952980A1

  公开（公告）日：1999-11-03
• SITE SELECTIVE ACYLATION
  申请人：ModPro AB

  公开号：EP1456226A1

  公开（公告）日：2004-09-15
• Site selective acylation
  申请人：Baltzer Lars

  公开号：US20060234291A1

  公开（公告）日：2006-10-19

  Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No. 3, SEQ. ID No. 4, SEQ. ID No. 5, or SEQ. ID No. 7, or one has a sequence according to SEQ. ID No. 6, and the other one has a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No. 3, SEQ. ID No. 4, SEQ. ID No. 5 or SEQ. ID No. 7. Also disclosed is a method for site-selective acylation of a folded polypeptide or protein based on the use of a four helix bundle formed of two dimerized helix-loop-helix motifs folded in an antiparallel mode, said helix-loop-helix motifs comprising amino acid residues in a heptad repeat pattern (a b c d e f g) n , wherein all but 1-3 of said amino acid residues in positions a and d are non-polar and wherein said 1-3 amino acid residues in positions a and d that are non-polar, are selected from the group consisting of lysine, ornithine, diaminobutyric acid and homolysine, wherein said amino acid residues in positions a and d form a hydrophobic core, wherein the polypeptide and/or protein to be acylated is placed in an aqueous solution and an acylation agent is added.
• US6171819B1
  申请人：——

  公开号：US6171819B1

  公开（公告）日：2001-01-09
• US7514222B2
  申请人：——

  公开号：US7514222B2

  公开（公告）日：2009-04-07