2-[(4,7-difluoro-2-methyl-1H-indol-5-yl)oxy]-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-N-[5-[(E)-prop-1-enyl]-1H-pyrazol-3-yl]pyrimidin-4-amine | 1609119-14-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(4,7-difluoro-2-methyl-1H-indol-5-yl)oxy]-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-N-[5-[(E)-prop-1-enyl]-1H-pyrazol-3-yl]pyrimidin-4-amine
• CAS: 1609119-14-3
• 化学式: C₂₅H₂₅F₂N₇O
• 分子量: 477.517
• InChiKey: OLBBUWNOGLKWTC-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (E)-6-chloro-2-((4,7-difluoro-2-methyl-1H-indol-5-yl)oxy)-N-(5-(prop-1-en-1-yl)-1H-pyrazol-3-yl)pyrimidin-4-amine 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 水 为溶剂， 反应 44.17h， 生成 2-[(4,7-difluoro-2-methyl-1H-indol-5-yl)oxy]-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-N-[5-[(E)-prop-1-enyl]-1H-pyrazol-3-yl]pyrimidin-4-amine
  参考文献：
  名称：

  [EN] SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
  [FR] DÉRIVÉS INDOL-5-OLE SUBSTITUÉS ET LEURS APPLICATIONS THÉRAPEUTIQUES

  摘要：

  公开号：

  WO2014071378A9

文献信息

• Substituted indol-5-ol derivatives and their therapeutic applications
  申请人：NantBioScience, Inc.

  公开号：US10245261B2

  公开（公告）日：2019-04-02

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.

  本发明一般涉及使用化合物治疗各种失调、疾病和病理状况，更具体地说，涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
• SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：NANT HOLDINGS IP, LLC

  公开号：US20150291564A1

  公开（公告）日：2015-10-15

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
• SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
  申请人：NANTBIOSCIENCE, INC

  公开号：US20160016945A1

  公开（公告）日：2016-01-21

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
• US9458137B2
  申请人：——

  公开号：US9458137B2

  公开（公告）日：2016-10-04
• US9550760B2
  申请人：——

  公开号：US9550760B2

  公开（公告）日：2017-01-24