2-(6'-azido-2',3',4'-tri-O-benzoyl-6'-deoxy-β-D-glucopyranosyl)-1,4-dimethoxybenzene | 1093850-32-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(6'-azido-2',3',4'-tri-O-benzoyl-6'-deoxy-β-D-glucopyranosyl)-1,4-dimethoxybenzene
• CAS: 1093850-32-8
• 化学式: C₃₅H₃₁N₃O₉
• 分子量: 637.646
• InChiKey: IAAAAOZVRLMGNA-OXFURMMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.13
• 重原子数：
  47.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  155.35
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  2-(6'-azido-2',3',4'-tri-O-benzoyl-6'-deoxy-β-D-glucopyranosyl)-1,4-dimethoxybenzene 、 Isophthalsaeure-dipropargylester 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 二氯甲烷 、 水 为溶剂， 以94%的产率得到bis((1-(((2R,3R,4R,5S,6S)-3,4,5-tris(benzoyloxy)-6-(2,5-dimethoxyphenyl)-tetrahydro-2H-pyran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl) isophthalate
  参考文献：
  名称：

  Synthesis of triazole-linked β-C-glycosyl dimers as inhibitors of PTP1B

  摘要：

  Protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for type 2 diabetes. We have successfully synthesized dimeric acetylated and benzoylated beta-C-D-glucosyl and beta-C-D-galactosyl 1,4-dimethoxy benzenes or naphthalenes by click chemistry. These compounds were further transformed into the corresponding beta-C-D-glycosyl-1,4-quinone derivatives by CAN oxidation. The in vitro inhibition test showed that dimeric benzoylated beta-C-D-glycosyl 1,4-dimethoxybenzenes or 1,4-benzoquinones were good inhibitors of PTP1B (IC50: 0.62-0.88 mu M), with no significant difference between gluco and galacto derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.066
• 作为产物：
  描述：

  在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(6'-azido-2',3',4'-tri-O-benzoyl-6'-deoxy-β-D-glucopyranosyl)-1,4-dimethoxybenzene
  参考文献：
  名称：

  β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors

  摘要：

  beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.091