8-oxo-5,8-dihydroimidazo[4,5-g]quinoline-7-carbonitrile | 348617-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-oxo-5,8-dihydroimidazo[4,5-g]quinoline-7-carbonitrile
• 英文别名: 8-Oxo-1,5-dihydroimidazo[4,5-g]quinoline-7-carbonitrile
• CAS: 348617-48-1
• 化学式: C₁₁H₆N₄O
• 分子量: 210.195
• InChiKey: SBECHWMEQLRINB-UHFFFAOYSA-N

物化性质

• 沸点：
  534.3±50.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-oxo-5,8-dihydroimidazo[4,5-g]quinoline-7-carbonitrile 在 草酰氯 、 吡啶盐酸盐 作用下， 以 乙二醇乙醚 为溶剂， 生成 8-(3,4,5-trimethoxyanilino)imidazo[4,5-g]quinoline-7-carbonitrile
  参考文献：
  名称：

  8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors

  摘要：

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00524-3
• 作为产物：
  描述：

  7-azido-6-nitro-4-oxo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,4-dihydro-3-quinolinecarbonitrile 在 palladium on activated charcoal 咪唑 、 氢气 作用下， 生成 8-oxo-5,8-dihydroimidazo[4,5-g]quinoline-7-carbonitrile
  参考文献：
  名称：

  8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors

  摘要：

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00524-3

文献信息

• Tricyclic protein kinase inhibitors
  申请人：American Home Products Corporation

  公开号：US20010051620A1

  公开（公告）日：2001-12-13

  This invention provides compounds of formula 1, having the structure 1 which are useful as inhibitors of protein tyro sine kinase and are antiproliferative agents.

  这项发明提供了具有结构1的化合物，这些化合物可作为蛋白酪氨酸激酶的抑制剂，是抗增殖剂。
• [EN] TRICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS TRICYCLIQUES DE PROTEINE KINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001047892A1

  公开（公告）日：2001-07-05

  This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

  本发明提供了一种式子为(1)的化合物，它们可用作蛋白酪氨酸激酶的抑制剂并具有抗增殖作用。
• TRICYCLIC PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1242382A1

  公开（公告）日：2002-09-25
• US6638929B2
  申请人：——

  公开号：US6638929B2

  公开（公告）日：2003-10-28
• US7105531B2
  申请人：——

  公开号：US7105531B2

  公开（公告）日：2006-09-12