7-methoxy-9-methyl-3,4-dihydro-β-carboline | 90475-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-methoxy-9-methyl-3,4-dihydro-β-carboline
• 英文别名: Harmidin；7-methoxy-9-methyl-4,9-dihydro-3H-β-carboline；7-Methoxy-9-methyl-3,4-dihydropyrido[3,4-b]indole；7-methoxy-9-methyl-3,4-dihydropyrido[3,4-b]indole
• CAS: 90475-59-5
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: UQRVIRARGUQWGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  26.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-methoxy-9-methyl-3,4-dihydro-β-carboline 在 镍 正丁基锂 、 (Z)-(1-ethoxyprop-1-enyloxy)trimethylsilane 、 四丁基氟化铵 、 sodium hydride 、 sodium cyanoborohydride 、 对甲苯磺酸 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 丙酮 、 环己烯 为溶剂， 反应 43.75h， 生成 (3aS,5aS,10bR,12bS)-3a-Ethyl-5-hydroxy-8-methoxy-6-methyl-4-oxo-12a-oxy-3a,4,5,5a,6,11,12,12b-octahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
  参考文献：
  名称：

  A new efficient total synthesis of vindorosine and vindoline

  摘要：

  DOI：

  10.1021/jo00207a011
• 作为产物：
  描述：

  N_b-formyl-N_a-methyl-6-methoxytryptamine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以88%的产率得到7-methoxy-9-methyl-3,4-dihydro-β-carboline
  参考文献：
  名称：

  A new efficient total synthesis of vindorosine and vindoline

  摘要：

  DOI：

  10.1021/jo00207a011

文献信息

• PRE-OPERATIVE BEVERAGES
  申请人：Santé, LLC

  公开号：US20150283072A1

  公开（公告）日：2015-10-08

  The invention provides a formulated beverage composition that can be administered to a patient, prior to anesthesia, sedation and/or surgical or dental operation, to reduce the risk of aspiration pneumonia while simultaneously improving the well-being of the patient. The beverage composition is designed to be taken orally, by a patient, within a specified short period of time prior to administration of an anesthesia and/or sedative/analgesic. Further described herein is the method of using the beverage composition. The method may include providing a written label of instructions affixed to the beverage container which instructions positively direct the patient's ingestion of the beverage composition.
• [EN] PRE-OPERATIVE BEVERAGES<br/>[FR] BOISSONS PRÉOPÉRATOIRES
  申请人：SANTÉ LLC

  公开号：WO2015142611A1

  公开（公告）日：2015-09-24

  The invention provides a formulated beverage composition that can be administered to a patient, prior to anesthesia, sedation and/or surgical or dental operation, to reduce the risk of aspiration pneumonia while simultaneously improving the well-being of the patient. The beverage composition is designed to be taken orally, by a patient, within a specified short period of time prior to administration of an anesthesia and/or sedative/analgesic. Further described herein is the method of using the beverage composition. The method may include providing a written label of instructions affixed to the beverage container which instructions positively direct the patient's ingestion of the beverage composition.
• A new efficient total synthesis of vindorosine and vindoline
  作者：Ratremaniaina Zo Andriamialisoa、Nicole Langlois、Yves Langlois

  DOI：10.1021/jo00207a011

  日期：1985.4