(2R,3S,4S,5R,6S)-2-(aminomethyl)-N-cyclohexyl-4,5,6-trimethoxytetrahydro-2H-pyran-3-amine | 1607435-28-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6S)-2-(aminomethyl)-N-cyclohexyl-4,5,6-trimethoxytetrahydro-2H-pyran-3-amine
• CAS: 1607435-28-8
• 化学式: C₁₅H₃₀N₂O₄
• 分子量: 302.414
• InChiKey: IFSXSVFPLPUKGR-FQKPHLNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.64
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.97
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5R,6S)-2-(aminomethyl)-N-cyclohexyl-4,5,6-trimethoxytetrahydro-2H-pyran-3-amine 、 硫代异氰酸苯酯 以 甲醇 为溶剂， 反应 4.0h， 以450 mg的产率得到methyl 4-cyclohexylamino-4,6-dideoxy-2,3-di-O-methyl-6-(N'-phenyl)thioureido-α-D-galactopyranoside
  参考文献：
  名称：

  Preparation of new type of organocatalysts having a carbohydrate scaffold

  摘要：

  The synthesis of nine new, bifunctional organocatalysts having carbohydrate scaffolds has been accomplished. In these catalysts both of the catalytic amino and thiourea functions are directly attached to a carbohydrate core. The activities of the newly prepared catalysts were tested in a Michael addition. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.12.026
• 作为产物：
  描述：

  methyl 4-O-benzoyl-6-bromo-6-deoxy-2,3-di-O-methyl-α-D-glucopyranoside 在 1,3-丙二硫醇 、 sodium azide 、 三氟甲磺酸酐 、 sodium methylate 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 67.0h， 生成 (2R,3S,4S,5R,6S)-2-(aminomethyl)-N-cyclohexyl-4,5,6-trimethoxytetrahydro-2H-pyran-3-amine
  参考文献：
  名称：

  Preparation of new type of organocatalysts having a carbohydrate scaffold

  摘要：

  The synthesis of nine new, bifunctional organocatalysts having carbohydrate scaffolds has been accomplished. In these catalysts both of the catalytic amino and thiourea functions are directly attached to a carbohydrate core. The activities of the newly prepared catalysts were tested in a Michael addition. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.12.026