2-[(2-Chloro-7-methoxyquinolin-3-yl)methylideneamino]phenol | 1236132-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(2-Chloro-7-methoxyquinolin-3-yl)methylideneamino]phenol
• CAS: 1236132-80-1
• 化学式: C₁₇H₁₃ClN₂O₂
• 分子量: 312.755
• InChiKey: WCWWJYCGFHASTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(2-Chloro-7-methoxyquinolin-3-yl)methylideneamino]phenol 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  An Efficient Synthesis and Antibacterial Screening of Novel Oxazepine α-Aminophosphonates by Ultrasound Approach

  摘要：

  An efficient synthesis of novel alpha-aminophosphonates by the reaction of quino[2,3-b][1,5]benzoxazepines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst p-toluene sulphonic acid (p-TSA). This method affords the alpha-aminophosphonates under the influence of ultrasound irradiation in solvent-free conditions, in short reaction times (4-6 min), high yields (80-90%), with improved purity. The synthesized alpha-aminophosphonates show antibacterial activity against Gram-positive and Gram-negative bacteria.

  DOI：

  10.1080/10426500802713259
• 作为产物：
  描述：

  2-氯-7-甲氧基喹啉-3-甲醛 、 2-氨基苯酚 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 2-[(2-Chloro-7-methoxyquinolin-3-yl)methylideneamino]phenol
  参考文献：
  名称：

  An Efficient Synthesis and Antibacterial Screening of Novel Oxazepine α-Aminophosphonates by Ultrasound Approach

  摘要：

  An efficient synthesis of novel alpha-aminophosphonates by the reaction of quino[2,3-b][1,5]benzoxazepines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst p-toluene sulphonic acid (p-TSA). This method affords the alpha-aminophosphonates under the influence of ultrasound irradiation in solvent-free conditions, in short reaction times (4-6 min), high yields (80-90%), with improved purity. The synthesized alpha-aminophosphonates show antibacterial activity against Gram-positive and Gram-negative bacteria.

  DOI：

  10.1080/10426500802713259

文献信息

• An Efficient Synthesis and Antibacterial Screening of Novel Oxazepine α-Aminophosphonates by Ultrasound Approach
  作者：Swapnil S. Sonar、Sandip A. Sadaphal、Vilas B. Labade、Bapurao B. Shingate、Murlidhar S. Shingare

  DOI：10.1080/10426500802713259

  日期：2009.12.29

  An efficient synthesis of novel alpha-aminophosphonates by the reaction of quino[2,3-b][1,5]benzoxazepines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst p-toluene sulphonic acid (p-TSA). This method affords the alpha-aminophosphonates under the influence of ultrasound irradiation in solvent-free conditions, in short reaction times (4-6 min), high yields (80-90%), with improved purity. The synthesized alpha-aminophosphonates show antibacterial activity against Gram-positive and Gram-negative bacteria.