(S)-{2-[2-amino-5-(tert-butyldimethylsilanyloxy)phenyl]-2-oxoethyl}-2,2-dimethyl[1,3]dioxolan-4-one | 929006-14-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-{2-[2-amino-5-(tert-butyldimethylsilanyloxy)phenyl]-2-oxoethyl}-2,2-dimethyl[1,3]dioxolan-4-one
• 英文别名: (5S)-5-[2-[2-amino-5-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-oxoethyl]-2,2-dimethyl-1,3-dioxolan-4-one
• CAS: 929006-14-4
• 化学式: C₁₉H₂₉NO₅Si
• 分子量: 379.528
• InChiKey: BENYEQODBKLGTH-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-{2-[2-amino-5-(tert-butyldimethylsilanyloxy)phenyl]-2-oxoethyl}-2,2-dimethyl[1,3]dioxolan-4-one 在 吡啶 、 氟化氢吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (S)-2-(biphenyl-4-yl)-N-{2-[2-(2,2-dimethyl-5-oxo[1,3]dioxolan-4-yl)acetyl]-4-hydroxyphenyl}acetamide
  参考文献：
  名称：

  Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum

  摘要：

  Blepharismone (gamone 2) is a mating-inducing pheromone of the ciliate Blepharisma japonicum. N-Pyrenylbutyryl-blepharismone and N-biphenylacetyl-blepharismone, which are fluorescent derivatives of blepharismone, were synthesized as molecular probes for the gamone 2 receptor. Further, we proved that they have inhibitory activities against the blepharismone-induced monotypic pairing of B. japonicum. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2006.12.021
• 作为产物：
  描述：

  (S)-{4-(tert-butyl-dimethyl-silanyloxy)-2-[2-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4-yl)-acetyl]-phenyl}-carbamic acid tert-butyl ester 在 苯甲醚 、 三氟乙酸 作用下， 以 丙酮 为溶剂， 反应 9.0h， 以67%的产率得到(S)-{2-[2-amino-5-(tert-butyldimethylsilanyloxy)phenyl]-2-oxoethyl}-2,2-dimethyl[1,3]dioxolan-4-one
  参考文献：
  名称：

  Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum

  摘要：

  Blepharismone (gamone 2) is a mating-inducing pheromone of the ciliate Blepharisma japonicum. N-Pyrenylbutyryl-blepharismone and N-biphenylacetyl-blepharismone, which are fluorescent derivatives of blepharismone, were synthesized as molecular probes for the gamone 2 receptor. Further, we proved that they have inhibitory activities against the blepharismone-induced monotypic pairing of B. japonicum. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2006.12.021