2,3,4-tri-O-acetyl-1,5-anhydro-L-rhamnitol | 190316-99-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3,4-tri-O-acetyl-1,5-anhydro-L-rhamnitol
• 英文别名: 1,6-dideoxy-2,3,4-tri-O-acetyl-L-rhamnopyranose；tri-O-acetyl-1,5-anhydro-L-rhamnitol；Tri-O-acetyl-1,5-anhydro-L-rhamnit；[(3S,4S,5S,6S)-4,5-diacetyloxy-6-methyloxan-3-yl] acetate
• CAS: 190316-99-5
• 化学式: C₁₂H₁₈O₇
• 分子量: 274.271
• InChiKey: QPTFIDGGNPUDEM-CLVBZSDCSA-N

物化性质

• 沸点：
  314.3±31.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,3,4-tri-O-acetyl-1,5-anhydro-L-rhamnitol 在 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 2,3,4-三-O-乙酰基-6-脱氧-alpha-L-甘露糖基溴化物
  参考文献：
  名称：

  Nickel and Chiral Phosphoric Acid Cocatalysis Enables Synthesis of C-Acyl Glycosides

  摘要：

  DOI：

  10.1021/acs.orglett.3c04159
• 作为产物：
  描述：

  1,2,3,4-tetra-O-acetyl-L-rhamnopyranose 在 吡啶 、 三氟化硼乙醚 、 sodium methylate 、 镍 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 2,3,4-tri-O-acetyl-1,5-anhydro-L-rhamnitol
  参考文献：
  名称：

  Synthetic oligosaccharides related to group B streptococcal polysaccharides. 3. Synthesis of oligosaccharides corresponding to the common polysaccharide antigen of group B streptococci

  摘要：

  DOI：

  10.1021/jo00252a030

文献信息

• [EN] RADIOLABELED SUGARS FOR IMAGING OF FUNGAL INFECTIONS<br/>[FR] SUCRES RADIOMARQUÉS POUR L'IMAGERIE DES INFECTIONS FONGIQUES
  申请人：US HEALTH

  公开号：WO2021025984A1

  公开（公告）日：2021-02-11

  Disclosed herein are compounds having a structure according to Formula I and optionally Formula IV. Formula I Formula IV. The compounds may be radiolabeled compounds useful for diagnosis and/or imaging fungal infections. In such embodiments, at least one substituent is a radionuclide, such as 18F. Also disclosed are precursor compounds according to Formula I and/or IV that are useful for making the radiolabeled compounds. In such embodiments, the precursor compound comprises at least one leaving group suitable for introducing a radionuclide, such as 18F, at a desired position. Also disclosed are methods for making and using the compounds, including embodiments of a method for imaging and/or diagnosing a fungal infection in a subject.

  本文披露了具有结构的化合物，符合公式I和可选的公式IV。公式I 公式IV。这些化合物可用于诊断和/或成像真菌感染的放射标记化合物。在这些实施例中，至少一个取代基是放射性核素，如18F。还披露了根据公式I和/或IV的前体化合物，这些前体化合物可用于制备放射标记化合物。在这些实施例中，前体化合物包括至少一种适用于在所需位置引入放射性核素，如18F的离去基团。还披露了制备和使用这些化合物的方法，包括一种用于成像和/或诊断受试者真菌感染的方法的实施例。
• The Reduction of Acetylated Glycopyranosyl Bromides to 1,5-Anhydroglycitols with Lithium Aluminum Hydride. 1,5-Anhydro-L-rhamnitol
  作者：Robert K. Ness、Hewitt G. Fletcher、C. S. Hudson

  DOI：10.1021/ja01166a059

  日期：1950.10
• Additive-controlled synthesis of 1- and 2-deoxysugars from thioglycosides
  作者：Xia Wu、Biao Wu、Chen-Fei Gao、Xin-Shan Ye、De-Cai Xiong

  DOI：10.1080/07328303.2021.2015366

  日期：2021.11.22
• NOVEL ANTI-AGING AND DEPIGMENTING COSMETIC COMPOSITIONS
  申请人：Frison Natacha

  公开号：US20150004110A1

  公开（公告）日：2015-01-01

  The 1-aryl-2-aryloxyethane compounds of Formula 1 in which n and m are zero or equal to 1, provided that n+m=1, R 1 and R 2 in particular representing hydrogen atoms, R 3 and R 4 in particular representing hydrogen atoms, halogen atoms, hydroxy or alkoxy groups, and R 5 in particular representing hydrogen atoms, hydroxy, alkyl, alkoxy, amino or nitro groups, in cosmetic compositions intended for anti-ageing and/or depigmenting and/or anti-inflammatory and/or wound-healing care.
• COMPOUNDS AND THERAPEUTIC USES THEREOF
  申请人：AVVINITY THERAPEUTICS LIMITED

  公开号：US20210353765A1

  公开（公告）日：2021-11-18

  The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.