2,2-dicarboethoxycyclohexanone | 2969-93-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-dicarboethoxycyclohexanone
• 英文别名: 1,1-Bis-aethoxycarbonyl-cyclohexanon-(2)；2,2-Dicarbaethoxy-cyclohexanon；Diethyl 2-oxocyclohexane-1,1-dicarboxylate
• CAS: 2969-93-9
• 化学式: C₁₂H₁₈O₅
• 分子量: 242.272
• InChiKey: WFFNBDLXWJGXCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2-dicarboethoxycyclohexanone 在 吡啶 、 sodium tetrahydroborate 、 三氟甲磺酸酐 、 phosphate buffer pH 7.2 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 73.0h， 生成 (R)-1-ethoxycarbonyl-2-cyclohexene-1-carboxylic acid
  参考文献：
  名称：

  Chemoenzymatic synthesis of an α-substituted serine derivative

  摘要：

  An asymmetric synthesis of an alpha-substituted serine derivative was achieved by employing PLE-catalyzed hydrolysis of a prochiral malonate derivative, and the absolute configuration of the hydrolyzed product was unambiguously determined by the X-ray analysis of a camphorsulfonic acid derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00270-0
• 作为产物：
  描述：

  氯甲酸乙酯 、 2-环己酮甲酸乙酯 在 magnesium(II) perchlorate 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2,2-dicarboethoxycyclohexanone
  参考文献：
  名称：

  The Acylation of β-Keto Esters. Control of the Position of Acylation by Variation of the Acylating Agent and Solvent^1a

  摘要：

  DOI：

  10.1021/jo01018a061

文献信息

• Pesticidal compounds
  申请人：The Wellcome Foundation Limited

  公开号：US05098929A1

  公开（公告）日：1992-03-24

  A compound of the formula (I): ##STR1## wherein R is C.sub.2-10 alkyl, alkenyl or alkynyl, each optionally subsituted by or methyl substituted by cyano, C.sub.3-4 cycloalkyl, halo, C.sub.1-4 alkoxy or a group S(O)mR.sup.4 where R.sup.4 is C.sub.1-4 alkyl and m is O, 1 or 2, or R is C.sub.3-10 cycloalkyl, C.sub.4-10 cycloalkenyl or phenyl, each optionally substituted by C.sub.1-4 alkoxy, C.sub.1-3 alkyl, C.sub.2-4 alkynyl, halo, cyano or a group S(O)mR.sup.4 as defined hereinbefore; R.sup.1 is halo, C.sub.1-3 alkyl, C.sub.2-3 alkenyl or alkynyl each optionally substituted by halo, cyano, C.sub.1-4 alkoxy, alkyl carbalkoxy containing up to 6 carbon atoms, a group S(O)mR.sup.4 as defined hereinbefore or alkynyl substituted by tri-C.sub.1-4 alkylsilyl, or R.sup.1 is cyano, spiro-cyclopropyl, gem dimethyl, oxo or methylene optionally substituted by cyano or C.sub.1-3 alkyl optionally substituted by fluorine, or R.sup.1 and R and the carbon atoms to which they are attached form a C.sub.5-7 carbocyclic ring optionally substituted by halo, C.sub.1-3 alkyl or alkoxy or C.sub. 2-3 alkenyl, R.sup.2 is phenyl, C.sub.5-10 cycloalkyl or cycloalkenyl each optionally substituted other than phenyl substituted by C.sub.2-3 alkynyl and R.sup.3 is hydrogen, C.sub.1-3 alkyl, C.sub.2-3 alkenyl or alkynyl each optionally substituted by cyano, C.sub.1-4 alkylthio, C.sub.1-4 alkoxy or halo, or R.sup.3 is cyano, its use in medicine, pharmaceutical compositions containing it and processes for its preparation.

  化合物的化学式（I）：##STR1## 其中R是C.sub.2-10烷基，烯基或炔基，每个都可以被氰基，C.sub.3-4环烷基，卤素，C.sub.1-4烷氧基或S（O）mR.sup.4基团取代，其中R.sup.4是C.sub.1-4烷基，m为O，1或2，或者R是C.sub.3-10环烷基，C.sub.4-10环烯基或苯基，每个都可以被C.sub.1-4烷氧基，C.sub.1-3烷基，C.sub.2-4炔基，卤素，氰基或如上所定义的S（O）mR.sup.4基团取代; R.sup.1是卤素，C.sub.1-3烷基，C.sub.2-3烯基或炔基，每个都可以被卤素，氰基，C.sub.1-4烷氧基，含有最多6个碳原子的烷基羰基烷氧基，如上所定义的S（O）mR.sup.4基团或炔基取代的三C.sub.1-4烷基硅基，或R.sup.1是氰基，螺环丙基，双甲基，氧代或亚甲基，可选择地被氰基或C.sub.1-3烷基取代，可选择地被氟取代，或R.sup.1和R及其附着的碳原子形成一个C.sub.5-7碳环，可选择地被卤素，C.sub.1-3烷基或烷氧基或C.sub.2-3烯基取代，R.sup.2是苯基，C.sub.5-10环烷基或环烯基，每个都可以选择性地被取代，除苯基外还被C.sub.2-3炔基取代，R.sup.3是氢，C.sub.1-3烷基，C.sub.2-3烯基或炔基，每个都可以选择性地被氰基，C.sub.1-4烷基硫基，C.sub.1-4烷氧基或卤素取代，或R.sup.3是氰基，它在医药中的应用，含有它的制药组合物以及制备它的方法。
• Thermoplastic composition having high fluidity
  申请人：RHODIA OPERATIONS

  公开号：US10584241B2

  公开（公告）日：2020-03-10

  The invention concerns a thermoplastic composition having high fluidity in the molten state, comprising at least: (a) one thermoplastic polymer matrix; (b) one oligomer selected from cyclic ester oligomers, ether oligomers and mixtures thereof, said oligomer having a degree of polymerization of between 2 and 25; and (c) one phenolic polymer; said compounds (b) and (c) being present in a weight ratio (c)/(b) varying from 0.25 to 6, and preferably from approximately 0.75 to 2.75. The invention also concerns a process for producing a composite article from such a composition by impregnating a reinforcement such as a fabric or a preform, the composite article obtained according to this process, and the use of an oligomer (b) in combination with at least one phenolic polymer (c), as a plasticizing additive in a thermoplastic polymer matrix.

  本发明涉及一种在熔融状态下具有高流动性的热塑性组合物，该组合物至少包括 (a) 一种热塑性聚合物基体； (b) 一种选自环酯低聚物、醚低聚物及其混合物的低聚物，所述低聚物的聚合度在 2 至 25 之间；以及 (c) 一种酚类聚合物； 所述化合物(b)和(c)的重量比(c)/(b)在 0.25-6 之间，最好在 0.75-2.75 左右。 本发明还涉及一种通过浸渍织物或预型件等增强材料，用这种组合物生产复合材料制品的工艺，根据该工艺获得的复合材料制品，以及低聚物（b）与至少一种酚类聚合物（c）结合使用，作为热塑性聚合物基体中的增塑添加剂。
• POLYAMIDES A FLUIDITE ELEVEE
  申请人：Rhodia Opérations

  公开号：EP2483329A1

  公开（公告）日：2012-08-08
• ARTICLE COMPOSITE A BASE DE RESINES POLYAMIDES DE FAIBLES MASSES MOLECULAIRES
  申请人：Rhodia Operations

  公开号：EP2513203A1

  公开（公告）日：2012-10-24
• PROCEDE DE FABRICATION D'ARTICLES COMPOSITE A BASE DE POLYAMIDE
  申请人：Rhodia Operations

  公开号：EP2512785A1

  公开（公告）日：2012-10-24