4-甲基-3-喹啉羧酸 | 103907-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-甲基-3-喹啉羧酸
• 中文别名: [1,1'-联苯基]-3-甲醇,3',5'-二氟-
• 英文名称: 4-methylquinoline-3-carboxylic acid
• 英文别名: 4-Methyl-chinolin-3-carbonsaeure
• CAS: 103907-10-4
• 化学式: C₁₁H₉NO₂
• mdl: MFCD18448148
• 分子量: 187.198
• InChiKey: DVUSXQGMZHRAPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(2-acetyl-phenylimino)-dihydro-furan-2-one 在 sodium hydroxide 、 potassium permanganate 、 硫酸 作用下， 生成 4-甲基-3-喹啉羧酸
  参考文献：
  名称：

  Quinoline Analogs of Podophyllotoxin. II. Friedländer Reactions with Tetronic Acid: A General Method for the Preparation of 2-Hydroxymethyl-3-quinolinecarboxylic Acid Lactones¹

  摘要：

  DOI：

  10.1021/jo01106a051

文献信息

• [EN] INHIBITORS OF MALT1 AND USES THEREOF<br/>[FR] INHIBITEURS DE MALT1 ET LEURS UTILISATIONS
  申请人：UNIV CORNELL

  公开号：WO2018165385A1

  公开（公告）日：2018-09-13

  Provided herein are compounds that inhibit MALTl, a protein whose activity is responsible for constitutive NF-κΒ signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALTl -related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.

  本文提供了一些抑制MALT1的化合物，MALT1是一种蛋白质，其活性负责某些癌症（如激活的B细胞弥漫性大B细胞淋巴瘤（ABC-DLBCL））中的NF-κΒ信号。还提供了包含这些化合物的药物组合物和试剂盒，以及使用这些化合物在受试者中治疗MALT1相关疾病和疾病（如癌症）的方法，通过给予本文描述的化合物和/或组合物。
• Inhibitors of MALT1 and uses thereof
  申请人：Cornell University

  公开号：US11248007B2

  公开（公告）日：2022-02-15

  Provided herein are compounds that inhibit MALT1, a protein whose activity is responsible for constitutive NF-κB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALT1-related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.

  本文提供了抑制 MALT1 的化合物，MALT1 是一种蛋白质，其活性在某些癌症（如活化 B 细胞弥漫性大 B 细胞淋巴瘤（ABC-DLBCL））中负责组成型 NF-κB 信号转导。此外，还提供了包含所述化合物的药物组合物和试剂盒，以及通过施用所述化合物和/或组合物，用所述化合物治疗受试者MALT1相关疾病和失调（如癌症）的方法。
• Marion et al., Canadian Journal of Research, Section B: Chemical Sciences, 1946, vol. 24, p. 224,229
  作者：Marion et al.

  DOI：——

  日期：——
• INHIBITORS OF MALT1 AND USES THEREOF
  申请人：Cornell UNiversity

  公开号：US20200385405A1

  公开（公告）日：2020-12-10

  Provided herein are compounds that inhibit MALT1, a protein whose activity is responsible for constitutive NF-κB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALT1-related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.
• [EN] COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH<br/>[FR] COMPOSES UTILES DANS LES BIO-ESSAIS CFTR ET LEURS PROCEDES
  申请人：VERTEX PHARMA

  公开号：WO2007075946A1

  公开（公告）日：2007-07-05

  [EN] The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR- mediated diseases. The present invention also provides an assay for use in measuring CFTR correction.
  [FR] La présente invention concerne des composés utiles dans les bio-essais CFTR. L'invention concerne aussi des composés utiles dans le contrôle de l'activité CFTR dans des thérapies pour des maladies médiées par CFTR. L'invention se rapporte en outre à un bio-essai à utiliser pour mesurer la correction CFTR.