1-(3,4-Dimethoxyphenyl)-3-(4-nitrophenyl)propan-1-one | 110997-81-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(3,4-Dimethoxyphenyl)-3-(4-nitrophenyl)propan-1-one
• CAS: 110997-81-4
• 化学式: C₁₇H₁₇NO₅
• 分子量: 315.326
• InChiKey: WIWVATNWRAHOLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3,4-Dimethoxyphenyl)-3-(4-nitrophenyl)propan-1-one 在 palladium on activated charcoal 硫酸 、 氢气 、 溶剂黄146 作用下， 生成 4-[3-(3,4-dimethoxyphenyl)propyl]benzenamine
  参考文献：
  名称：

  Catechol based inhibitors of 15-lipoxygenase

  摘要：

  A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.

  DOI：

  10.1016/0960-894x(95)00565-b
• 作为产物：
  描述：

  3-(4-硝基苯基)丙酸 在 三氯化铝 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 1-(3,4-Dimethoxyphenyl)-3-(4-nitrophenyl)propan-1-one
  参考文献：
  名称：

  Catechol based inhibitors of 15-lipoxygenase

  摘要：

  A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.

  DOI：

  10.1016/0960-894x(95)00565-b

文献信息

• Novel enolamides, process for their manufacture and pharmaceutical compositions thereof with an activity as modulators of the arachidonic acid cascade
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0221345A1

  公开（公告）日：1987-05-13

  The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.

  本发明涉及新型烯酰胺类化合物、药物组合物及其使用方法，可用于治疗脂氧合酶酶活性产物或白三烯作用导致病理状态的疾病。
• (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0221346B1

  公开（公告）日：1991-01-30
• CARETHERA, MARY E.;CENTENKO, WIACZESLAW A.;CONNOR, DAVID T.;JOHNSON, ELIZ+
  作者：CARETHERA, MARY E.、CENTENKO, WIACZESLAW A.、CONNOR, DAVID T.、JOHNSON, ELIZ+

  DOI：——

  日期：——
• US4761424A
  申请人：——

  公开号：US4761424A

  公开（公告）日：1988-08-02
• US4868195A
  申请人：——

  公开号：US4868195A

  公开（公告）日：1989-09-19