(3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮 | 128-68-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮
• 中文别名: 2,2'-二羟基-4,4'-二甲基-1,1'-双环正己烷-1,1',4,4'-四烯-3,3',6,6'-四酮
• 英文名称: phoenicin
• 英文别名: phenicin；2,2'-dihydroxy-4,4'-dimethyl-[1,1']bicyclohexa-1,4-dienyl-3,6,3',6'-tetraone；2,2'-Dihydroxy-4,4'-dimethyl-[1,1']bicyclohexa-1,4-dienyl-3,6,3',6'-tetraon；2,2'-dihydroxy-4,4'-dimethyl-(bi-1,4-cyclohexadien-1-yl)-3,3',6,6'-tetrone；3.3'-Dihydroxy-5.5'-dimethyl-bi-p-benzochinonyl-(2.2')；2,2'-Dihydroxy-4,4'-dimethyl-3,6,3',6'-dibenzochinon；Phenicin；3-hydroxy-2-(2-hydroxy-4-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)-5-methylcyclohexa-2,5-diene-1,4-dione
• CAS: 128-68-7
• 化学式: C₁₄H₁₀O₆
• 分子量: 274.23
• InChiKey: BFRRTQSWBORPKV-UHFFFAOYSA-N

物化性质

• 熔点：
  230-231°
• 沸点：
  377.21°C (rough estimate)
• 密度：
  1.3918 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮 在 四氢吡咯 、 copper diacetate 、 盐酸 、 水 作用下， 以59%的产率得到卵孢霉素
  参考文献：
  名称：

  An efficient synthesis of oosporein

  摘要：

  Fungal metabolite oosporein was prepared in four steps and 24% overall yield starting from 2.5-dimethoxytoluene. It was demonstrated that treatment of phoenicin with pyrrolidine and copper(II) acetate led to oosporein, whereas similar treatment of the isomeric 'isophoenicin' produced a benzofuran diquinone. No chromatography was required during any step of the synthesis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.103
• 作为产物：
  描述：

  6-甲基-1,2,4-苯三醇 在 bis(1,3-propanediaminato)copper(II) chloride 氧气 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以65%的产率得到(3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮
  参考文献：
  名称：

  Oxidation of Hydroquinones with Oxygen in the Presence of Bis(1,3-propanediaminato)copper(II) Chloride

  摘要：

  在乙醇中将对苯二酚（如 1,2-二羟基苯、1,4-二羟基苯及其 2-甲基衍生物、1,2,4-三羟基-6-甲基苯、1,2-和 1,4- 二羟基萘）与氧气在双（1、3-丙二胺）氯化铜（II）和几滴乙酸的作用下，发生氧化 C-C 偶联反应，并将对苯二酚氧化成醌系，从而得到相应的生物醌，收率超过 75%。

  DOI：

  10.1055/s-1988-27745

文献信息

• Rust disease control by Aphanocladium album and/or Beauveria brongniartii
  申请人：Subbiah Ven

  公开号：US20070110726A1

  公开（公告）日：2007-05-17

  There is disclosed a method and composition for controlling rust disease in plants. Metabolites produced by Aphanocladium album mycoparasites are recovered and applied in an effective amount to plants at risk for acquiring rust disease More specifically, the application of the metabolite converts infective urediniospores that cause rust disease into non-infective teliospores. In a more specific aspect, the metabolite is reacted with another substance or under a specific reaction to result in a different compound which is also effective against rust disease.

  本发明揭示了一种用于控制植物锈病的方法和组合物。通过Aphanocladium album真菌寄生体产生的代谢物被提取并以有效量施用于有患锈病风险的植物上。更具体地，代谢物的施用将导致引起锈病的传染性锈子孢子转变为非传染性的子囊孢子。在更具体的方面，这种代谢物与另一种物质或在特定反应条件下反应，形成对锈病也有效的不同化合物。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
  申请人：Proteotech Inc.

  公开号：EP1808169A2

  公开（公告）日：2007-07-18

  Polyhydroxylated aromatic compounds, and compositions containing them, are useful for the treatment of amyloidosis, especially Alzheimer's disease, and for the treatment of diseases characterized by α-synuclein fibril formation, especially Lewy body disease and Parkinson's disease.

  多羟基芳香族化合物和含有它们的组合物可用于治疗淀粉样变性病，特别是阿尔茨海默病，以及治疗以α-突触核蛋白纤维形成为特征的疾病，特别是路易体病和帕金森病。
• Accelerators for increasing the rate of formation of free radicals and reactive oxygen species
  申请人：Cavalier Discovery

  公开号：US20030082101A1

  公开（公告）日：2003-05-01

  The formation of free radicals is enhanced with photodynamic agents, sonodynamic agents, and systems and therapies utilizing ultrasound by subjecting the agent to light waves or sound waves in the presence of a metal, a reductant, or a chelate, or mixtures thereof.

  光动力药剂、声动力药剂以及利用超声波的系统和疗法，在有金属、还原剂或螯合物或它们的混合物存在的情况下，使药剂受到光波或声波的作用，可促进自由基的形成。
• Musso; Beecken, Chemische Berichte, 1959, vol. 92, p. 1416,1422
  作者：Musso、Beecken

  DOI：——

  日期：——

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