(R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide} | 263024-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}
• CAS: 263024-62-0
• 化学式: C₄₁H₅₀N₂O₄P₂
• 分子量: 696.807
• InChiKey: UIPDLYSWTCLKOH-SIMZDOAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.05
• 重原子数：
  49.0
• 可旋转键数：
  14.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  76.66
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide} 在 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 96.0h， 以60%的产率得到(2R,3R)-N,N'-bis[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]-2,3-dihydroxy-succinediamide
  参考文献：
  名称：

  Synthesis of Heterofunctionalized Multidentate Diphosphines

  摘要：

  The synthesis of new chiral multidentate amino- and amidophosphine ligands bearing up to six potential coordination sites were synthesized starting from L-valine. Based on these compounds chiral Ru(II) complexes were prepared, characterized and tested in the asymmetric transfer hydrogenation of aryl-alkyl ketones. In all cases investigated the catalyst bearing additional hydroxy groups gave lower conversions than the complex without hydroxy groups. Highest enantioselectivity was achieved with isobutyrophenone as substrate (69%ee). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)01075-3
• 作为产物：
  描述：

  N-Boc-L-缬氨醇 在 吡啶 、 氢溴酸 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 溶剂黄146 为溶剂， 反应 18.0h， 生成 (R,R)-2,2-dimethyl-1,3-dioxolane-4,5-diacid-bis{[(1'S)-1'-(diphenylphosphinomethyl)-2'-methyl-propyl]amide}
  参考文献：
  名称：

  Synthesis of Heterofunctionalized Multidentate Diphosphines

  摘要：

  The synthesis of new chiral multidentate amino- and amidophosphine ligands bearing up to six potential coordination sites were synthesized starting from L-valine. Based on these compounds chiral Ru(II) complexes were prepared, characterized and tested in the asymmetric transfer hydrogenation of aryl-alkyl ketones. In all cases investigated the catalyst bearing additional hydroxy groups gave lower conversions than the complex without hydroxy groups. Highest enantioselectivity was achieved with isobutyrophenone as substrate (69%ee). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)01075-3