3-chloro-6-[2-(diethylamino)ethoxy]-10-[2-(diethylamino)ethyl]acridin-9(10H)-one | 1025901-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-chloro-6-[2-(diethylamino)ethoxy]-10-[2-(diethylamino)ethyl]acridin-9(10H)-one
• 英文别名: T3.5；3-(2-diethylaminoethoxy)-6-chloro-10-(2-diethyl-aminoethyl)-9-acridone；3-Chloro-6-[2-(diethylamino)ethoxy]-10-[2-(diethylamino)ethyl]acridin-9-one
• CAS: 1025901-28-3
• 化学式: C₂₅H₃₄ClN₃O₂
• 分子量: 444.017
• InChiKey: HBYNOUHPMCAFIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  36
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-chloro-6-hydroxyacridin-9(10H)-one 、 2-二乙氨基氯乙烷盐酸盐 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 生成 3-chloro-6-[2-(diethylamino)ethoxy]-10-[2-(diethylamino)ethyl]acridin-9(10H)-one
  参考文献：
  名称：

  WO2008/64011

  摘要：

  公开号：

文献信息

• ACRIDONE COMPOUNDS
  申请人：Riscoe Michael K.

  公开号：US20100069428A1

  公开（公告）日：2010-03-18

  A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.
• Acridone Compounds
  申请人：Government of the United States of America dba The Department of Veterans Affairs

  公开号：US20140128423A1

  公开（公告）日：2014-05-08

  A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.
• US8592447B2
  申请人：——

  公开号：US8592447B2

  公开（公告）日：2013-11-26
• US8987296B2
  申请人：——

  公开号：US8987296B2

  公开（公告）日：2015-03-24
• US9399625B2
  申请人：——

  公开号：US9399625B2

  公开（公告）日：2016-07-26