2-(α-ferrocenylethyl)indazole | 810659-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(α-ferrocenylethyl)indazole
• 英文别名: cyclopenta-1,3-diene;2-[(1S)-1-cyclopenta-2,4-dien-1-ylethyl]indazole;iron(2+)
• CAS: 810659-32-6；521943-91-9
• 化学式: C₁₉H₁₈FeN₂
• 分子量: 330.212
• InChiKey: MVNSOBOBDGGFHI-IDMXKUIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  2-(α-ferrocenylethyl)indazole 以 四氢呋喃 为溶剂， 以40%的产率得到1‐(1‐ferrocenylethyl)benzimidazole
  参考文献：
  名称：

  摘要：

  Ferrocenylmethylation and alpha-ferrocenylethylation of indazole were carried out for the first time. Both reactions afforded two isomers, which were characterized by physical and physicochemical methods, among them by X-ray diffraction analysis. 1-(alpha-Ferrocenylethyl)indazole is thermally more stable than the 2-substituted isomer. Both isomers serve as ferrocenylalkylating agents with respect to s-triazole.

  DOI：

  10.1023/a:1021360704054
• 作为产物：
  描述：

  吲唑 、 1-ferrocenylethanol 在 HBF₄ 、 NH₃ 作用下， 以 氯仿 、 水 为溶剂， 以62%的产率得到1‐(1‐ferrocenylethyl)benzimidazole
  参考文献：
  名称：

  摘要：

  Ferrocenylmethylation and alpha-ferrocenylethylation of indazole were carried out for the first time. Both reactions afforded two isomers, which were characterized by physical and physicochemical methods, among them by X-ray diffraction analysis. 1-(alpha-Ferrocenylethyl)indazole is thermally more stable than the 2-substituted isomer. Both isomers serve as ferrocenylalkylating agents with respect to s-triazole.

  DOI：

  10.1023/a:1021360704054

文献信息

• Synthesis and properties of optically active ferrocenylethylindazoles
  作者：A. A. Simenel、Yu. V. Kuzmenko、M. M. Ilyin、V. V. Gumenyuk、L. V. Snegur、Yu. S. Nekrasov

  DOI：10.1023/b:rucb.0000037868.08052.23

  日期：2004.4

  The stereochemistry of two processes, viz., alpha-ferrocenylalkylation of indazole with optically active S-(+)-1-ferrocenylethanol and the thermal rearrangement of S-(+)-2-N-(ferrocenylethyl)indazole into S-(+)-1-N-(ferrocenylethyl) indazole, was studied. Both reactions proceed stereoselectively.