Direct α-Arylation of α-Amino Carbonyl Compounds with Indoles Using Visible Light Photoredox Catalysis
作者:Zhi-Qiang Wang、Ming Hu、Xiao-Cheng Huang、Lu-Bing Gong、Ye-Xiang Xie、Jin-Heng Li
DOI:10.1021/jo301691h
日期:2012.10.5
A general and mild method for the construction of functionalized 2-(1H-indol-3-yl)-2-amino-carbonyl compounds was achieved, which represents the first example of direct alpha-arylation of alpha-amino carbonyl compounds with indoles using the visible light photoredox catalysis strategy.
The application discloses compounds of the Formula (A) wherein: or a pharmaceutically acceptable salt thereof, for the treatment of pain, genitourinary conditions, gastroenterological conditions, and respiratory conditions, via inhibition of P2X3 and P2X2/3.