N-nitro-3-ethylazetidin-3-ol | 155141-15-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-nitro-3-ethylazetidin-3-ol
• 英文别名: 3-Ethyl-1-nitroazetidin-3-ol
• CAS: 155141-15-4
• 化学式: C₅H₁₀N₂O₃
• 分子量: 146.146
• InChiKey: YMBGUFGMANOMAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-nitro-3-ethylazetidin-3-ol 在 4-二甲氨基吡啶 、 三氟甲磺酸酐 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以71%的产率得到N-Nitro-3-ethylideneazetidine
  参考文献：
  名称：

  Additions of X-Y Across the C(3)-N .sigma.-Bond in 1-Aza-3-ethylbicyclo[1.1.0]butane. Novel Routes to 3-Substituted Azetidines

  摘要：

  DOI：

  10.1021/jo00097a071
• 作为产物：
  描述：

  1-ethyl-3-azabicyclo<1.1.0>butane 在 sodium hydroxide 、 硝酸 、 dinitrogen tetraoxide 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 2.92h， 生成 N-nitro-3-ethylazetidin-3-ol
  参考文献：
  名称：

  Reactions of 1-ethyl-3-azabicyclo[1.1.0]butane with electrophiles. A facile entry into new, N-substituted 3-ethylideneazetidines and 2-azetines

  摘要：

  Reaction of 1-aza-3-ethylbicyclo [1.1.0]butane (3) with N2O4 under a variety of experimental conditions afforded several products, 4-7, all of which resulted via addition across the strained central C(3)-N sigma-bond in 3. The corresponding reactions of ClCO(2)Et, Tf(2)O, and Ms(2)O with 3 also have been studied. These reactions provide useful methods for synthesizing N-substituted 3-ethylideneazetidines and 2-azetines.

  DOI：

  10.1021/jo00086a008

文献信息

• Reactions of 1-ethyl-3-azabicyclo[1.1.0]butane with electrophiles. A facile entry into new, N-substituted 3-ethylideneazetidines and 2-azetines
  作者：Alan P. Marchand、D. Rajagopal、Simon G. Bott、Thomas G. Archibald

  DOI：10.1021/jo00086a008

  日期：1994.4

  Reaction of 1-aza-3-ethylbicyclo [1.1.0]butane (3) with N2O4 under a variety of experimental conditions afforded several products, 4-7, all of which resulted via addition across the strained central C(3)-N sigma-bond in 3. The corresponding reactions of ClCO(2)Et, Tf(2)O, and Ms(2)O with 3 also have been studied. These reactions provide useful methods for synthesizing N-substituted 3-ethylideneazetidines and 2-azetines.
• Additions of X-Y Across the C(3)-N .sigma.-Bond in 1-Aza-3-ethylbicyclo[1.1.0]butane. Novel Routes to 3-Substituted Azetidines
  作者：Alan P. Marchand、D. Rajagopal、Simon G. Bott、Thomas G. Archibald

  DOI：10.1021/jo00097a071

  日期：1994.9