(2R,3R)-2-(5-methoxycyclohexa-1,4-dienyl)-4-methylpentan-2-ol | 795279-40-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R)-2-(5-methoxycyclohexa-1,4-dienyl)-4-methylpentan-2-ol
• 英文别名: (2S,3R)-2-(5-methoxycyclohexa-1,4-dien-1-yl)-4-methylpentan-3-ol
• CAS: 795279-40-2
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: UULXCKAKIZVIOF-GXFFZTMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,3R)-2-(5-methoxycyclohexa-1,4-dienyl)-4-methylpentan-2-ol 在 吡啶 、 三乙酰氧基硼氢化钠 、 臭氧 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (4R,5S,6R)-4-羟基-6-异丙基-5-甲基四氢-2H-吡喃-2-酮
  参考文献：
  名称：

  Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B

  摘要：

  Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.07.044
• 作为产物：
  描述：

  (2S,3R)-2-(3-methoxyphenyl)-4-methylpentan-3-ol 在 氨 、 lithium 、 异丙醇 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (2R,3R)-2-(5-methoxycyclohexa-1,4-dienyl)-4-methylpentan-2-ol
  参考文献：
  名称：

  Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B

  摘要：

  Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.07.044

文献信息

• Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B
  作者：Varinder K. Aggarwal、Imhyuck Bae、Hee-Yoon Lee

  DOI：10.1016/j.tet.2004.07.044

  日期：2004.10

  Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. (C) 2004 Elsevier Ltd. All rights reserved.