4-bromo-2-ethoxy-6-fluorobenzaldehyde | 1638951-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-bromo-2-ethoxy-6-fluorobenzaldehyde
• CAS: 1638951-93-5
• 化学式: C₉H₈BrFO₂
• 分子量: 247.064
• InChiKey: PCVSUPHHCNMYTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-bromo-2-ethoxy-6-fluorobenzaldehyde 在 potassium phosphate 、 copper(l) iodide 、 一水合肼 、 (1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 反应 30.0h， 生成 (6-(6-bromo-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol
  参考文献：
  名称：

  [EN] IRAK4 INHIBITING AGENTS
  [FR] AGENTS D'INHIBITION DE L'IRAK 4

  摘要：

  公开号：

  WO2016011390A8
• 作为产物：
  描述：

  4-溴-2-氟-6-甲氧基苯甲醛 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 4-bromo-2-ethoxy-6-fluorobenzaldehyde
  参考文献：
  名称：

  [EN] IRAK4 INHIBITING AGENTS
  [FR] AGENTS D'INHIBITION DE L'IRAK 4

  摘要：

  公开号：

  WO2016011390A8

文献信息

• [EN] HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS DIONE CYCLIQUES (ALKYNYL-PHÉNYLE)-SUBSTITUÉS À ACTIVITÉ HERBICIDE ET LEURS DÉRIVÉS
  申请人：SYNGENTA LTD

  公开号：WO2014191534A1

  公开（公告）日：2014-12-04

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclopentane-1,3-dione-2-yl, a cyclohexane-1,3, 5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, or a cycloheptane-1,3-dione-2-yl, or a derivative thereof (e.g. a fused such as fused bicyclic derivative, and/or a spirocyclic derivative), or an enol ketone tautomer derivative thereof, wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R1 is fluorine; and/or R2 is -O-R2A, wherein R2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or -CH2CH2OCH3. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

  本发明涉及一种具有以下结构的化合物（I）：其中：X是甲基或氯；R1是氟或溴；R2是乙炔基，C1-C3烷氧基，C1-C3卤代烷氧基，或C1-C3烷氧基-C1-C3烷氧基；Q是吡喃-3,5-二酮-4-基，硫代吡喃-3,5-二酮-4-基，哌啶-3,5-二酮-4-基，环戊二酮-2-基，环己三酮-2-基，环己二酮-2-基，或环庚二酮-2-基，或其衍生物（例如，融合的如融合的双环衍生物和/或螺环衍生物），或其烯醇酮互变异构体衍生物，其中Q在此进一步定义；化合物（I）可作为农药接受的盐存在。优选，X是甲基；和/或R1是氟；和/或R2是-O-R2A，其中R2A是甲基，乙基，三氟甲基，二氟甲基，三氟乙基，或-CH2CH2OCH3。这些化合物适用于作为除草剂使用。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将化合物（I）或含有该化合物的除草剂组合物施用于杂草和/或植物和/或其生长环境。
• [EN] HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS DIONES CYCLIQUES (ALKYL-PHÉNYL)-SUBSTITUÉS ACTIFS DU POINT DE VUE HERBICIDE ET LEURS DÉRIVÉS
  申请人：SYNGENTA LTD

  公开号：WO2014191535A1

  公开（公告）日：2014-12-04

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclohexane-1,3,5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, a cycloheptane-1,3-dione-2-yl, in which each cyclic dione is bridged by alkanediyl, or a derivative thereof (e.g. an enol ketone tautomer derivative thereof), wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R1 is fluorine; and/or R2 is -O-R2A, wherein R2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or -CH2CH2OCH3. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

  本发明涉及一种化合物，其化学式为（I）：其中：X为甲基或氯；R1为氟或溴；R2为乙炔基，C1-C3烷氧基，C1-C3卤代烷氧基，或C1-C3烷氧基-C1-C3烷氧基-；Q为吡喃-3,5-二酮-4-基，硫代吡喃-3,5-二酮-4-基，哌啶-3,5-二酮-4-基，环己烷-1,3,5-三酮-2-基，环己烷-1,3-二酮-2-基，环庚烷-1,3-二酮-2-基，其中每个环状二酮由烷二基桥接，或其衍生物（例如烯醇酮互变异构体衍生物），Q在此进一步定义；化合物的化学式（I）可作为农药中可接受的盐存在。优选，X为甲基；和/或R1为氟；和/或R2为-O-R2A，其中R2A为甲基，乙基，三氟甲基，二氟甲基，三氟乙基，或-CH2CH2OCH3。这些化合物适用于作为除草剂使用。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将化合物（I）或含有该化合物的除草剂组合物施用于杂草和/或植物和/或其生长环境的方法。
• Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof
  申请人：SYNGENTA LIMITED

  公开号：US20160207934A1

  公开（公告）日：2016-07-21

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R 1 is fluorine or bromine; R 2 is ethynyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, or C 1 -C 3 alkoxy-C 1 -C 3 alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclopentane-1,3-dione-2-yl, a cyclohexane-1,3, 5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, or a cycloheptane-1,3-dione-2-yl, or a derivative thereof (e.g. a fused such as fused bicyclic derivative, and/or a spirocyclic derivative), or an enol ketone tautomer derivative thereof, wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R 1 is fluorine; and/or R 2 is —O—R 2A , wherein R 2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or —CH 2 CH 2 OCH 3 . These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

  本发明涉及一种式为（I）的化合物：其中：X为甲基或氯；R1为氟或溴；R2为乙炔基，C1-C3烷氧基，C1-C3卤代烷氧基，或C1-C3烷氧基-C1-C3烷氧基-；而Q为吡喃-3,5-二酮-4-基，噻吩-3,5-二酮-4-基，哌啶-3,5-二酮-4-基，环戊-1,3-二酮-2-基，环己-1,3,5-三酮-2-基，环己-1,3-二酮-2-基或环庚-1,3-二酮-2-基，或其衍生物（例如融合的双环衍生物和/或螺环衍生物），或其烯醇酮互变异构体衍生物，其中Q在此进一步定义；化合物（I）可以选择作为农药可接受的盐存在。优选地，X为甲基；和/或R1为氟；和/或R2为-O-R2A，其中R2A为甲基，乙基，三氟甲基，二氟甲基，三氟乙基或-CH2CH2OCH3。这些化合物适用于用作除草剂。因此，本发明还涉及一种控制作物中有用植物的杂草，特别是草本单子叶杂草的方法，包括将式为（I）的化合物或包含这种化合物的除草剂组合物施用于杂草和/或植物和/或其所在地点。
• Herbicidally Active (alkynyl-phenyl)-Substituted Cyclic Dione Compounds and Derivatives Thereof
  申请人：SYNGENTA LIMITED

  公开号：US20160143277A1

  公开（公告）日：2016-05-26

  The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R 1 is fluorine or bromine; R 2 is ethynyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, or C 1 -C 3 alkoxy-C 1 -C 3 alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclohexane-1,3,5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, a cycloheptane-1,3-dione-2-yl, in which each cyclic dione is bridged by alkanediyl, or a derivative thereof (e.g. an enol ketone tautomer derivative thereof), wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R 1 is fluorine; and/or R 2 is —O—R 2A , wherein R 2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or —CH 2 CH 2 OCH 3 . These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

  本发明涉及一种式（I）的化合物：其中：X为甲基或氯；R1为氟或溴；R2为乙炔基，C1-C3烷氧基，C1-C3卤代烷氧基或C1-C3烷氧基-C1-C3烷氧基-；Q为吡喃-3,5-二酮-4-基，硫代吡喃-3,5-二酮-4-基，哌啶-3,5-二酮-4-基，环己烷-1,3,5-三酮-2-基，环己烷-1,3-二酮-2-基，环庚烷-1,3-二酮-2-基，其中每个环二酮由烷二基桥接，或其衍生物（例如，烯醇酮互变异构体衍生物），其中Q在此进一步定义；并且式（I）的化合物可以作为农药可接受的盐存在。优选地，X为甲基；和/或R1为氟；和/或R2为—O—R2A，其中R2A为甲基，乙基，三氟甲基，二氟甲基，三氟乙基，或—CH2CH2OCH3。这些化合物适用于作为除草剂使用。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物的作物中的方法，包括将式（I）的化合物或包含这种化合物的除草剂组合物应用于杂草和/或植物和/或其生长地点。
• UREA COMPOUND FOR ANTAGONIZING LPA1 RECEPTOR
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP4008405A1

  公开（公告）日：2022-06-08

  The present invention provides a compound represented by formula [I] having an LPA1 receptor-antagonizing action, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种由式[I]所表示的化合物，其具有LPA1受体拮抗作用，或其药学上可接受的盐。