β-2-fluoro-2-deoxyglucose-6-phosphate | 99257-09-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-2-fluoro-2-deoxyglucose-6-phosphate
• 英文别名: [(2R,3S,4S,5R,6R)-5-fluoro-3,4,6-trihydroxyoxan-2-yl]methyl dihydrogen phosphate
• CAS: 99257-09-7
• 化学式: C₆H₁₂FO₈P
• 分子量: 262.129
• InChiKey: ONTILDPWDCZIPX-QZABAPFNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-脱氧-2-氟-d-赖氨酸 生成 2-脱氧-2-氟-beta-D-吡喃葡萄糖 、 2-脱氧-2-氟-d-赖氨酸 、 α-2-fluoro-2-deoxymannose-6-phosphate 、 α-2-fluoro-2-deoxyglucose-6-phosphate 、 β-2-fluoro-2-deoxymannose-6-phosphate 、 β-2-fluoro-2-deoxyglucose-6-phosphate
  参考文献：
  名称：

  Metabolic pathway of 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose in mice bearing sarcoma 180 studied by fluorin-19 nuclear magnetic resonance.

  摘要：

  通过氟-19核磁共振（19F-NMR）光谱研究了在小鼠体内移植的肉瘤180细胞中2-脱氧-2-氟-D-葡萄糖（FDG）和2-脱氧-2-氟-D-甘露糖（FDM）的代谢产物。结果表明，所施用的FDG在肿瘤细胞中转化为FDM（和/或FDM-6-磷酸），施用的FDM也转化为FDG（和/或FDG-6-磷酸）。施用FDM后9小时，FDG（和/或FDG-6-磷酸）与FDM（和/或FDM-6-磷酸）的比例达到平衡。另一方面，施用FDG后需要超过48小时。在这两种情况下，FDM（和/或FDM-6-磷酸）的平衡量大约是FDG（和/或FDG-6-磷酸）的四倍。

  DOI：

  10.1248/cpb.36.1194

文献信息

• Metabolic pathway of 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose in mice bearing sarcoma 180 studied by fluorin-19 nuclear magnetic resonance.
  作者：MASAHARU KOJIMA、SATORU KURIBAYASHI、YOKO KANAZAWA、TERUSHI HARADAHIRA、YOSHIHIKO MAEHARA、HIDEYA ENDO

  DOI：10.1248/cpb.36.1194

  日期：——

  The metabolic products of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-fluoro-D-mannose (FDM) in sarcoma 180 cells transplanted in mice were investigated by fluorin-19 nuclear magnetic resonance (19F-NMR) spectroscopy. It became apparent that the administered FDG was converted to FDM (and/or FDM-6-phosphate) in tumor cells, and also the administered FDM was converted to FDG (and/or FDG-6-phosphate). At 9h after administration of FDM, the ratio of FDG (and/or FDG-6-phosphate) and FDM (and/or FDM-6-phosphate) reached equilibrium. On the other hand, it took more than 48h in the case of FDG administration. The equilibrium amount of FDM (and/or FDM-6-phosphate) was approximately four times as much as that of FDG (and/or FDG-6-phosphate) in both cases.

  通过氟-19核磁共振（19F-NMR）光谱研究了在小鼠体内移植的肉瘤180细胞中2-脱氧-2-氟-D-葡萄糖（FDG）和2-脱氧-2-氟-D-甘露糖（FDM）的代谢产物。结果表明，所施用的FDG在肿瘤细胞中转化为FDM（和/或FDM-6-磷酸），施用的FDM也转化为FDG（和/或FDG-6-磷酸）。施用FDM后9小时，FDG（和/或FDG-6-磷酸）与FDM（和/或FDM-6-磷酸）的比例达到平衡。另一方面，施用FDG后需要超过48小时。在这两种情况下，FDM（和/或FDM-6-磷酸）的平衡量大约是FDG（和/或FDG-6-磷酸）的四倍。