(E)-3-(3-hydroxy-4-methoxy-phenyl)-N-(3-hydroxy-phenyl)-acrylamide | 1223570-35-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(3-hydroxy-4-methoxy-phenyl)-N-(3-hydroxy-phenyl)-acrylamide
• 英文别名: (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(3-hydroxyphenyl)prop-2-enamide
• CAS: 1223570-35-1
• 化学式: C₁₆H₁₅NO₄
• 分子量: 285.299
• InChiKey: COPQRMDHUSNHSO-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-3-(3-hydroxy-4-methoxy-phenyl)-N-(3-hydroxy-phenyl)-acrylamide 、 3-氯甲基吡啶盐酸盐 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (E)-3-(3-Hydroxy-4-methoxy-phenyl)-N-[3-(pyridin-3-ylmethoxy)-phenyl]-acrylamide
  参考文献：
  名称：

  Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition

  摘要：

  本文描述了丙烯酰胺衍生物作为治疗剂，特别是用于预防和/或治疗与线粒体通透性转换孔（MPTP）活性相关的疾病和病症，例如缺血/再灌注、氧化或退行性组织损伤等疾病。这些化合物属于结构式（I），其中R、R'、R"、W和a如规范中所定义。本发明还涉及这些化合物的制备，以及包含它们的制药组合物。

  公开号：

  EP2179984A1

文献信息

• ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION
  申请人：Fancelli Daniele

  公开号：US20110195977A1

  公开（公告）日：2011-08-11

  Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.

  本文描述了丙烯酰胺衍生物作为治疗剂的有用性，特别是用于预防和/或治疗与线粒体通透性转换孔（MPTP）活性相关的疾病和病症，例如缺血/再灌注、氧化或退行性组织损伤等疾病。这些化合物属于结构式（I），其中R，R'，R''，W和a的定义如规范中所述。本发明还涉及这些化合物的制备，以及包含它们的药物组合物。
• Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition
  申请人：Fancelli Daniele

  公开号：US08669261B2

  公开（公告）日：2014-03-11

  Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.

  本文描述了丙烯酰胺衍生物作为治疗剂的用途，特别是用于预防和/或治疗与线粒体通透性转换孔（MPTP）的活性相关的疾病和病症，如缺血/再灌注、氧化或变性组织损伤等疾病。这些化合物属于结构式（I），其中R，R'，R"，W和a如规范中定义。本发明还涉及这些化合物的制备，以及包含它们的制药组合物。
• ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION
  申请人：Fancelli Daniele

  公开号：US20130245019A1

  公开（公告）日：2013-09-19

  Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.

  本文描述了丙烯酰胺衍生物作为治疗剂的用途，特别是用于预防和/或治疗与线粒体通透性转换孔（MPTP）活性相关的疾病和病症，例如缺血/再灌注、氧化或变性组织损伤等疾病。这些化合物属于结构式（I），其中R、R'、R"、W和a的定义如规范中所述。本发明还涉及这些化合物的制备，以及包含它们的制药组合物。
• US8470831B2
  申请人：——

  公开号：US8470831B2

  公开（公告）日：2013-06-25
• US8669261B2
  申请人：——

  公开号：US8669261B2

  公开（公告）日：2014-03-11