(R)-3-methoxydecan-1-ol | 185954-75-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-methoxydecan-1-ol
• 英文别名: (3R)-3-Methoxydecan-1-OL
• CAS: 185954-75-0
• 化学式: C₁₁H₂₄O₂
• 分子量: 188.31
• InChiKey: FVSDHZHOJJXJTA-LLVKDONJSA-N

物化性质

• 沸点：
  262.1±8.0 °C(Predicted)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-3-methoxydecan-1-ol 在 对甲苯磺酸 、 lithium hexamethyldisilazane 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 二甲基亚砜 为溶剂， 反应 11.5h， 生成 (R,E)-7-methoxytetradec-4-en-1-ol
  参考文献：
  名称：

  Novel malyngamide structural analogs: synthesis and biological evaluation

  摘要：

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.

  DOI：

  10.1007/s00044-013-0466-y
• 作为产物：
  描述：

  (R)-decane-1,3-diol 在 咪唑 、 4-二甲氨基吡啶 、 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 反应 30.5h， 生成 (R)-3-methoxydecan-1-ol
  参考文献：
  名称：

  Novel malyngamide structural analogs: synthesis and biological evaluation

  摘要：

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.

  DOI：

  10.1007/s00044-013-0466-y

文献信息

• Substituted Liposaccharides Useful in the Treatment and Prevention of Endotoxemia
  申请人：Christ William J.

  公开号：US20080214802A1

  公开（公告）日：2008-09-04

  Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.
• SUBSTITUTED LIPOSACCHARIDES USEFUL IN THE TREATMENT AND PREVENTION OF ENDOTOXEMIA
  申请人：Christ William J.

  公开号：US20100227835A1

  公开（公告）日：2010-09-09

  Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.
• US7737129B2
  申请人：——

  公开号：US7737129B2

  公开（公告）日：2010-06-15
• US7994154B2
  申请人：——

  公开号：US7994154B2

  公开（公告）日：2011-08-09
• Novel malyngamide structural analogs: synthesis and biological evaluation
  作者：G. Venkateswar Reddy、T. Vijaya Kumar、B. Siva、K. Suresh Babu、P. V. Srinivas、Irum Sehar、A. K. Saxena、J. Madhusudana Rao

  DOI：10.1007/s00044-013-0466-y

  日期：2013.10

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.