8-((prop-2-yn-1-yloxy)methyl)pentadeca-5,10-diyne | 1311202-05-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-((prop-2-yn-1-yloxy)methyl)pentadeca-5,10-diyne
• CAS: 1311202-05-7
• 化学式: C₁₉H₂₈O
• 分子量: 272.431
• InChiKey: JYOSSMZTQZGFKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  20.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  8-((prop-2-yn-1-yloxy)methyl)pentadeca-5,10-diyne 、 氯甲酸乙酯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 12.0h， 以58%的产率得到ethyl 4-((2-(hept-2-yn-1-yl)non-4-yn-1-yl)oxy)but-2-ynoate
  参考文献：
  名称：

  Chain-Growth Cycloaddition Polymerization via a Catalytic Alkyne [2 + 2 + 2] Cyclotrimerization Reaction and Its Application to One-Shot Spontaneous Block Copolymerization

  摘要：

  A cobalt-catalyzed alkyne [2 + 2 + 2] cycloaddition reaction has been applied to polymerizations yielding linear polymers via selective cross-cyclotrimerization of yne-diyne monomers, which occurs in a chain-growth manner. Additionally, through control of the alkyne reactivity of the two monomers, this method was efficiently applied to the spontaneous block copolymerization of their mixture. Here we present the proposed mechanism of the catalyst transfer process of this cycloaddition polymerization.

  DOI：

  10.1021/ja203584c
• 作为产物：
  描述：

  2-(hept-2-yn-1-yl)non-4-yn-1-ol 、 3-溴丙炔 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 13.0h， 生成 8-((prop-2-yn-1-yloxy)methyl)pentadeca-5,10-diyne
  参考文献：
  名称：

  Chain-Growth Cycloaddition Polymerization via a Catalytic Alkyne [2 + 2 + 2] Cyclotrimerization Reaction and Its Application to One-Shot Spontaneous Block Copolymerization

  摘要：

  A cobalt-catalyzed alkyne [2 + 2 + 2] cycloaddition reaction has been applied to polymerizations yielding linear polymers via selective cross-cyclotrimerization of yne-diyne monomers, which occurs in a chain-growth manner. Additionally, through control of the alkyne reactivity of the two monomers, this method was efficiently applied to the spontaneous block copolymerization of their mixture. Here we present the proposed mechanism of the catalyst transfer process of this cycloaddition polymerization.

  DOI：

  10.1021/ja203584c