[(E,2S,3S,4S,5R,10S,11R,12S)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-11-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyl-13-phenylmethoxytridec-7-enoxy]-tert-butyl-dimethylsilane | 916240-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E,2S,3S,4S,5R,10S,11R,12S)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-11-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyl-13-phenylmethoxytridec-7-enoxy]-tert-butyl-dimethylsilane
• CAS: 916240-58-9
• 化学式: C₅₀H₉₀O₆Si₃
• 分子量: 871.517
• InChiKey: FOWHSBIMPZEFOD-GUGWUABSSA-N

物化性质

• 沸点：
  738.6±60.0 °C(Predicted)
• 密度：
  0.947±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.48
• 重原子数：
  59
• 可旋转键数：
  27
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [(E,2S,3S,4S,5R,10S,11R,12S)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-11-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyl-13-phenylmethoxytridec-7-enoxy]-tert-butyl-dimethylsilane 在 镍 氢气 作用下， 以 乙醇 为溶剂， 以85%的产率得到(2S,3R,4S,9R,10S,11S,12S)-9,11,13-tris[[tert-butyl(dimethyl)silyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyltridecan-1-ol
  参考文献：
  名称：

  A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin

  摘要：

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.004
• 作为产物：
  描述：

  (2S,3R,4S)-5-benzyloxy-2,3-dimethylpentane-1,4-diol 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 草酰氯 、 camphor-10-sulfonic acid 、 三氯化硼 、 四氯化锡 、 二异丁基氢化铝 、 戴斯-马丁氧化剂 、 二甲基亚砜 、 三乙胺 、 N,N-二异丙基乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 56.5h， 生成 [(E,2S,3S,4S,5R,10S,11R,12S)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-11-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyl-13-phenylmethoxytridec-7-enoxy]-tert-butyl-dimethylsilane
  参考文献：
  名称：

  A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin

  摘要：

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.004

文献信息

• A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin
  作者：V. Sai Baba、Parthasarathi Das、K. Mukkanti、Javed Iqbal

  DOI：10.1016/j.tetlet.2006.09.004

  日期：2006.11

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.