1-[[(2S,3R,4S)-2,4-dimethyl-1-phenylmethoxyhept-6-en-3-yl]oxymethyl]-4-methoxybenzene | 916240-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[[(2S,3R,4S)-2,4-dimethyl-1-phenylmethoxyhept-6-en-3-yl]oxymethyl]-4-methoxybenzene
• CAS: 916240-59-0
• 化学式: C₂₄H₃₂O₃
• 分子量: 368.516
• InChiKey: NLLBIRXIHGXQLC-MZLICYQSSA-N

物化性质

• 沸点：
  470.7±45.0 °C(Predicted)
• 密度：
  1.011±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[[(2S,3R,4S)-2,4-dimethyl-1-phenylmethoxyhept-6-en-3-yl]oxymethyl]-4-methoxybenzene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 镍 氢气 作用下， 以 乙醇 为溶剂， 反应 36.0h， 生成 (2S,3R,4S,9R,10S,11S,12S)-9,11,13-tris[[tert-butyl(dimethyl)silyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2,4,10,12-tetramethyltridecan-1-ol
  参考文献：
  名称：

  A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin

  摘要：

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.004
• 作为产物：
  描述：

  (2S,3R,4S)-5-benzyloxy-2,3-dimethylpentane-1,4-diol 在 草酰氯 、 camphor-10-sulfonic acid 、 sodium hexamethyldisilazane 、 二异丁基氢化铝 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 26.5h， 生成 1-[[(2S,3R,4S)-2,4-dimethyl-1-phenylmethoxyhept-6-en-3-yl]oxymethyl]-4-methoxybenzene
  参考文献：
  名称：

  A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin

  摘要：

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.004

文献信息

• A cross metathesis approach to the synthesis of the C11–C23 fragment of (−)-16-normethyldictyostatin
  作者：V. Sai Baba、Parthasarathi Das、K. Mukkanti、Javed Iqbal

  DOI：10.1016/j.tetlet.2006.09.004

  日期：2006.11

  The synthesis of the C11-C23 fragment 2 of (-)-16-normethyldictyostatin has been achieved by cross metathesis between two olefinic fragments 4 and 5 followed by a reduction of the double bond at C16-C17. Both the olefinic fragments are easily synthesized in a diastereoselective manner from the common precursor alcohol 7. (c) 2006 Elsevier Ltd. All rights reserved.