(R)十六烷-1,3-二醇 | 334830-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (R)十六烷-1,3-二醇
• 英文名称: (R)-hexadecane-1,3-diol
• 英文别名: (3R)-hexadecane-1,3-diol
• CAS: 334830-70-5
• 化学式: C₁₆H₃₄O₂
• 分子量: 258.445
• InChiKey: GZXNLYGAGAVUSB-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)十六烷-1,3-二醇 在 palladium on activated charcoal potassium permanganate 、 potassium dihydrogenphosphate 、 TEA 、 氢气 、 1-羟基苯并三唑 、 对甲苯磺酸 、 红铝 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 生成 反式-2-十六碳二烯酸
  参考文献：
  名称：

  The synthesis of pseudomycin C′ via a novel acid promoted side-chain deacylation of pseudomycin A

  摘要：

  The gamma hydroxyl present in the aliphatic side chain of the natural products pseudomycin A and C' provided a unique handle for the pH dependent side-chain deacylation. Low pH reaction conditions were used to cleave the side chain with minimal degradation of the peptide core. The pseudomycin nucleus intermediate obtained from the deacylation of pseudomycin A was pivotal in the synthesis of novel side-chain analogues. A practical synthesis of a minor fermentation factor pseudomycin C' and related analogues is reported. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00613-2
• 作为产物：
  描述：

  3-羟基十六烷酸甲酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 (R)十六烷-1,3-二醇
  参考文献：
  名称：

  Termination of the structural confusion between plipastatin A1 and fengycin IX

  摘要：

  Plipastatin A1 and fengycin IX were experimentally proven to be identical compounds, while these had been considered as diastereomers due to the permutation of the enantiomeric pair of Tyr in most papers. The H-1 NMR spectrum changed to become quite similar to that of plipastatin A1, when the sample which provided resembled spectrum of fengycin IX was treated with KOAc followed by LH-20 gel filtration. Our structural investigations disclosed that the structures of these molecules should be settled into that of plipastatin A1 by Umezawa (L-Tyr4 and D-Tyr10). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.04.040

文献信息

• Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
  作者：Dávid Roman、Philippe Meisinger、Richard Guillonneau、Chia‐Chi Peng、Lukas K. Peltner、Paul M. Jordan、Veit Haensch、Sebastian Götze、Oliver Werz、Christian Hertweck、Yin Chen、Christine Beemelmanns

  DOI：10.1002/anie.202401195

  日期：——

  The planar structure of a newly reported group of bacterial sulfur-containing aminolipids was revised and their absolute configuration determined by a combination of analytical techniques, isolation, degradation experiments, and total synthesis. The revised structures, termed cysteinolides, diverge from previous homotaurine-based proposals, revealing a composition of a cysteinolic acid containing head

  对新报道的一组细菌含硫氨基脂的平面结构进行了修改，并通过分析技术、分离、降解实验和全合成的结合确定了它们的绝对构型。修改后的结构被称为半胱氨酸内酯，与之前基于同牛磺酸的提议不同，揭示了含有被各种（α-羟​​基）羧酸酰化的头基的半胱氨酸的组成。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210108198A1

  公开（公告）日：2021-04-15

  The present application relates to extracting a plurality of compounds from a traditional Chinese medicine, or synthesizing a compound capable of promoting nucleic acid delivery, and utilizing the extracted compound, or a plurality of combinations to promote absorption and entry of a nucleic acid such as sRNA into a target cell, and to facilitate the entry of a nucleic acid into a target site in a subject in need thereof.
• EXTRACTION OF PLANT SOURCE "MEDICINAL SOUP" AND MANUAL PREPARATION OF "HERBAL MEDICINE" AND RELATED PRODUCTS
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210113641A1

  公开（公告）日：2021-04-22

  Provided is a method for preparing bencaosome comprising the steps of: mixing one or more lipid components with any one or more of the following: nucleic acid, compound and mancromolecules, and treating the obtained mixture by heating. Also provided is a method for extracting decoctosome from plants comprising the steps of: preparing an extract of the plant with a solvent; performing differential centrifugation to the extract; resuspending the precipitates with an aqueous solution to provide the decoctosome.
• The synthesis of pseudomycin C′ via a novel acid promoted side-chain deacylation of pseudomycin A
  作者：Michael J Rodriguez、Matthew Belvo、Robert Morris、Douglas J Zeckner、William L Current、Roberta K Sachs、Mark J Zweifel

  DOI：10.1016/s0960-894x(00)00613-2

  日期：2001.1

  The gamma hydroxyl present in the aliphatic side chain of the natural products pseudomycin A and C' provided a unique handle for the pH dependent side-chain deacylation. Low pH reaction conditions were used to cleave the side chain with minimal degradation of the peptide core. The pseudomycin nucleus intermediate obtained from the deacylation of pseudomycin A was pivotal in the synthesis of novel side-chain analogues. A practical synthesis of a minor fermentation factor pseudomycin C' and related analogues is reported. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Termination of the structural confusion between plipastatin A1 and fengycin IX
  作者：Miho Honma、Kazuaki Tanaka、Katsuhiro Konno、Kenji Tsuge、Toshikatsu Okuno、Masaru Hashimoto

  DOI：10.1016/j.bmc.2012.04.040

  日期：2012.6

  Plipastatin A1 and fengycin IX were experimentally proven to be identical compounds, while these had been considered as diastereomers due to the permutation of the enantiomeric pair of Tyr in most papers. The H-1 NMR spectrum changed to become quite similar to that of plipastatin A1, when the sample which provided resembled spectrum of fengycin IX was treated with KOAc followed by LH-20 gel filtration. Our structural investigations disclosed that the structures of these molecules should be settled into that of plipastatin A1 by Umezawa (L-Tyr4 and D-Tyr10). (C) 2012 Elsevier Ltd. All rights reserved.