(E)-3-phenyl-1-(pyrazin-2-yl)prop-2-en-1-one | 74475-90-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-phenyl-1-(pyrazin-2-yl)prop-2-en-1-one
• 英文别名: 3-phenyl-1-pyrazin-2-yl-propenone；3-Phenyl-1-pyrazin-2-yl-prop-2-en-1-one；(E)-3-phenyl-1-pyrazin-2-ylprop-2-en-1-one
• CAS: 74475-90-4
• 化学式: C₁₃H₁₀N₂O
• 分子量: 210.235
• InChiKey: BLDCTMNFFOVJQC-VOTSOKGWSA-N

物化性质

• 熔点：
  104-107 °C(Solv: ethanol (64-17-5))
• 沸点：
  378.2±42.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 (E)-3-phenyl-1-(pyrazin-2-yl)prop-2-en-1-one 在 manganese(III) triacetate dihydrate 作用下， 反应 3.0h， 以59%的产率得到trans-6,6-dimethyl-3-phenyl-2-(pyrazine-2-carbonyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one
  参考文献：
  名称：

  Unexpected Solvent-Free Cycloadditions of 1,3-Cyclohexanediones to 1-(Pyridin-2-yl)-enones Mediated by Manganese(III) Acetate in a Ball Mill

  摘要：

  Under solvent-free ball-milling conditions, manganese(III) acetate dihydrate-mediated cycloadditions of 5,5-dimethyl-1,3-cyclohexanedione and 1,3-cyclohexanedione to various 1-(pyridin-2-yl)-enones proceeded efficiently to afford trans-2-acyl-3-aryl/alkyl-2,3.6,7-tetrahydro-4(5H)-benzofuranone derivatives. The cyclization reactions exhibited good to excellent yields, as well as extremely high diastereoselectivity and unexpected regioselectivity. Manganese(III) acetate behaved both as an oxidant and as a Lewis acid.

  DOI：

  10.1021/jo800870z
• 作为产物：
  描述：

  2-甲酸吡嗪 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 噻吩-2-甲酸亚铜(I) 、 三(2-呋喃基)膦 、 三乙基膦 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 (E)-3-phenyl-1-(pyrazin-2-yl)prop-2-en-1-one
  参考文献：
  名称：

  硫醇酯-硼酸偶联。机械上前所未有的通用酮合成

  摘要：

  DOI：

  10.1021/ja005613q

文献信息

• Zamocka, Jirina; Dvorackova, Dasa; Heger, Jozef, Zeitschrift fur Chemie, 1980, vol. 20, # 1, p. 29 - 30
  作者：Zamocka, Jirina、Dvorackova, Dasa、Heger, Jozef

  DOI：——

  日期：——
• DVORACHOVA D.; ZAMOCKA J.; HEGER J.; NAGY A.; HARTELOVA V., CHEM. ZVESTI, 1980, 34, NO 2, 263-268
  作者：DVORACHOVA D.、 ZAMOCKA J.、 HEGER J.、 NAGY A.、 HARTELOVA V.

  DOI：——

  日期：——
• ZAMOCKA J.; DVORACKOVA D.; HEGER J.; MLYNARCIK D., CHEM. ZVESTI, 1980, 34 NO 4, 550-555
  作者：ZAMOCKA J.、 DVORACKOVA D.、 HEGER J.、 MLYNARCIK D.

  DOI：——

  日期：——
• ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS
  申请人：ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

  公开号：US20220015338A1

  公开（公告）日：2022-01-20

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION
  申请人：ZHUHAI QiWEl BIO-TECHNOLOGY LTD.

  公开号：US20220016146A1

  公开（公告）日：2022-01-20

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.