1-(2,4-二羟基-3-甲基苯基)-1-丁酮 | 93970-93-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2,4-二羟基-3-甲基苯基)-1-丁酮
• 英文名称: 2,4-dihydroxy-3-methylbutyrophenone
• 英文别名: 1-(2,4-dihydroxy-3-methyl-phenyl)-butan-1-one；1-(2,4-Dihydroxy-3-methyl-phenyl)-butan-1-on；2',4'-dihydroxy-3'-methylbutyrophenone；1-(2,4-dihydroxy-3-methylphenyl)butan-1-one
• CAS: 93970-93-5
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: CJDDRLSUHGAYKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2914400090

反应信息

• 作为反应物：
  描述：

  1-(2,4-二羟基-3-甲基苯基)-1-丁酮 在 叠氮基三甲基硅烷 、 二正丁基氧化锡 、 potassium carbonate 作用下， 以 丙酮 、 甲苯 为溶剂， 生成 1-(2-hydroxy-3-methyl-4-{4-[4-(2H-tetrazol-5-yl)-phenoxy]-butoxy}-phenyl)-butan-1-one
  参考文献：
  名称：

  Phenyl-tetrazolyl Acetophenones:  Discovery of Positive Allosteric Potentiatiors for the Metabotropic Glutamate 2 Receptor

  摘要：

  Herein we disclose the discovery of a new class of positive allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2), phenyl-tetrazolyl acetophenones, e.g. 1-(2-hydroxy-3-propyl-4-{4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy}phenyl) ethanone (4). These potentiators were shown to have no effect in the absence of glutamate as well as no effect at mGlu3 or the other mGlu receptors. The compounds were also evaluated in rodent models with potential relevance for schizophrenia, and 4 was shown to have activity in the inhibition of ketamine-induced norepinephrine release and ketamine-induced hyperactivity. This represents the first example of the efficacy of mGlu2 receptor potentiators in these models.

  DOI：

  10.1021/jm040088h
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢碘酸 、 乙酸酐 作用下， 生成 1-(2,4-二羟基-3-甲基苯基)-1-丁酮
  参考文献：
  名称：

  Shah; Shah, Journal of the Indian Chemical Society, 1940, vol. 17, p. 32,34

  摘要：

  DOI：

文献信息

• Ytterbium triflate catalysed Friedel–Crafts reaction using carboxylic acids as acylating reagents under solvent-free conditions
  作者：Can Jin、Jie Li、Weike Su

  DOI：10.3184/030823409x12511347683523

  日期：2009.10

  The Friedel–Crafts acylation of 1-naphthol and phenol derivatives with carboxylic acids were investigated by using a catalytic amount of metal-triflate, in particular Yb(OTf)3, under solvent-free conditions. Both aliphatic and aromatic carboxylic acids reacted easily to afford the corresponding hydroxyaryl ketones.

  在无溶剂条件下，通过使用催化量的金属三氟甲磺酸盐，特别是 Yb(OTf)3，研究了 1-萘酚和苯酚衍生物与羧酸的 Friedel-Crafts 酰化反应。脂肪族和芳香族羧酸都容易反应得到相应的羟基芳基酮。
• CHROMONE DERIVATIVE HAVING OSTEOGENESIS PROMOTING EFFECT
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20140349991A1

  公开（公告）日：2014-11-27

  Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof:

  用于促进骨生成、改善骨代谢、预防或治疗骨折、预防或治疗与骨代谢相关的疾病，或在骨科领域促进骨折、骨缺损和骨关节炎等骨疾病的愈合，以及在牙科领域用于治疗牙周病和稳定人工牙根的化合物或其药理学可接受的盐。这些化合物由式(I)或其药理学可接受的盐表示：
• Acetophenone potentiators of metabotropic glutamate receptors
  申请人：Cube V. Rowena

  公开号：US20050288346A1

  公开（公告）日：2005-12-29

  The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及激活型代谢型谷氨酸受体的化合物，包括mGluR2受体，适用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗涉及代谢型谷氨酸受体的疾病。
• Image making medium
  申请人：——

  公开号：US20030035917A1

  公开（公告）日：2003-02-20

  The invention relates to an image support medium for creation of an aesthetic image that is an work or object for display. This support medium includes a polymer in an amount sufficient to enable the image to have at least one aesthetic element. In different embodiments, the image support medium is an image support stabilizer, the polymer is a synthetic absorbent or conductive polymer, or the polymer is a transparent or synthetic translucent polymer and a property of this transparent or translucent polymer is enhanced to facilitate the creation or preservation of the image by at least one stabilizer. The invention also relates to a method for preparing this image support medium. The method includes forming a reaction mixture comprising a monomer in an amount sufficient to provide or enable the image to have an aesthetic element, and processing the reaction mixture into a 2- or 3-dimensional shape.

  本发明涉及一种图像支持介质，用于创建作为作品或展示对象的美学图像。这种支撑介质包括一种聚合物，其用量足以使图像具有至少一种审美元素。在不同的实施例中，图像支持介质是一种图像支持稳定剂，聚合物是一种合成的吸收性或导电性聚合物，或者聚合物是一种透明或合成的半透明聚合物，并且这种透明或半透明聚合物的特性被至少一种稳定剂增强，以促进图像的创建或保存。本发明还涉及一种制备这种图像支持介质的方法。该方法包括形成由单体组成的反应混合物，其用量足以提供或使图像具有美学元素，并将反应混合物加工成 2 维或 3 维形状。
• [EN] ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS<br/>[FR] POTENTIALISATEURS ACETOPHENONES DES RECEPTEURS METABOTROPIQUES DU GLUTAMATE
  申请人：MERCK & CO INC

  公开号：WO2004018386A3

  公开（公告）日：2004-11-25

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